Early Magnetic Resonance Imaging and Cognitive Markers of Hereditary Cerebral Amyloid Angiopathy.
Early Magnetic Resonance Imaging and Cognitive Markers of Hereditary Cerebral Amyloid Angiopathy.
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DOI：
10.1161/strokeaha.116.014418
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发表时间：
2016-12
期刊：
影响因子：
8.3
通讯作者：
van Buchem MA
中科院分区：
文献类型：
--
作者：
van Rooden S;van Opstal AM;Labadie G;Terwindt GM;Wermer MJ;Webb AG;Middelkoop HA;Greenberg SM;van der Grond J;van Buchem MA
Early markers for cerebral amyloid angiopathy (CAA) are largely unknown. We aimed to identify which MRI (performed at 7 tesla and 3 tesla) and cognitive markers are an early sign in (pre-)symptomatic subjects with Hereditary Cerebral Hemorrhage With Amyloidosis-Dutch type (HCHWA-D). Twenty-seven DNA-proven Dutch type mutation carriers (15 symptomatic and 12 pre-symptomatic) (mean age of 45.9) and 33 controls (mean age of 45.6) were included. 7T and 3T MRI was performed, CAA and small vessel disease type MRI markers were estimated, and cognitive performance was assessed. Univariate general linear modeling analysis was used to assess the association between MRI markers and cognitive performance on the one hand, and on the other mutation status, adjusted for age, sex and education. In symptomatic patients, all established CAA MRI markers (microbleeds, intracerebral hemorrhages, subarachnoid hemorrhages, superficial siderosis, microinfarcts, volume of white matter hyperintensities (WMHs) and dilated perivascular spaces in centrum semiovale) were increased compared to controls (p<0.05). In pre-symptomatic subjects, the prevalence of microinfarcts and median volume of WMHs were increased in comparison to controls (p<0.05). Symptomatic patients performed worse on all cognitive domains, whereas pre-symptomatic subjects did not show differences in comparison with controls (p<0.05). WMHs and microinfarcts are more prevalent among pre-symptomatic subjects and precede cognitive and neuropsychiatric symptoms and intracerebral hemorrhages.
