Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338
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DOI：
10.1038/nbt1297
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发表时间：
2007-04-01
影响因子：
46.9
通讯作者：
Leadlay, Peter F.
中科院分区：
文献类型：
--
作者：
Oliynyk, Markiyan;Samborskyy, Markiyan;Leadlay, Peter F.
红多孢菌用于抗生素红霉素A的工业规模生产，红霉素A的衍生物在医学中起着至关重要的作用。该土壤细菌的测序染色体包含8，212，805个碱基对，预测编码7，264个基因。它是圆形的，像致病放线菌结核分枝杆菌和白喉棒状杆菌的那些，但不像模式放线菌天蓝色链霉菌A3（2）和密切相关的阿维链霉菌的线性染色体。色葡萄拟南芥基因组包含至少25个用于产生已知或预测的次级代谢产物的基因簇，至少72个预测赋予对一系列常见抗生素类的抗性的基因，以及许多组重复的基因，以支持其嗜杀的生活方式。利用S.该公司将提高对其生物学的认识，并促进菌株的合理开发，以产生临床重要抗生素的高滴度生产者。
Saccharopolyspora erythraea is used for the industrial- scale production of the antibiotic erythromycin A, derivatives of which play a vital role in medicine. The sequenced chromosome of this soil bacterium comprises 8,212,805 base pairs, predicted to encode 7,264 genes. It is circular, like those of the pathogenic actinomycetes Mycobacterium tuberculosis and Corynebacterium diphtheriae, but unlike the linear chromosomes of the model actinomycete Streptomyces coelicolor A3( 2) and the closely related Streptomyces avermitilis. The S. erythraea genome contains at least 25 gene clusters for production of known or predicted secondary metabolites, at least 72 genes predicted to confer resistance to a range of common antibiotic classes and many sets of duplicated genes to support its saprophytic lifestyle. The availability of the genome sequence of S. erythraea will improve insight into its biology and facilitate rational development of strains to generate high- titer producers of clinically important antibiotics.