EVALUATION OF A PRESSURE SORE MODEL USING MONOPLEGIC PIGS
EVALUATION OF A PRESSURE SORE MODEL USING MONOPLEGIC PIGS
复制标题
DOI：
10.1097/00006534-199508000-00025
复制
发表时间：
1995-08-01
影响因子：
3.6
通讯作者：
BROWNE, EZ
中科院分区：
文献类型：
--
作者：
HYODO, A;REGER, SI;BROWNE, EZ
这项研究通过测试初始伤口大小的一致性来评估新开发的猪单瘫压疮模型。并对其自然愈合情况进行评价。共使用了9只小型猪。切断单侧L1~S2神经根，失神经支配后肢。术后5~14d，用直径3 cm的圆盘将皮肤和皮下组织按压在股骨粗隆部位的失神经皮肤上，持续48h。然后对伤口进行清创，去除血管组织。根据照片计算创面面积。通过测量填充伤口缺损处所需的生理盐水的体积来获得伤口体积。所有猪都出现了大小一致的全层溃疡，没有死亡或并发症。创面面积和体积最初增加，达到峰值，然后以指数形式减少。该模型为短期和长期研究中压疮治疗方法的直接比较提供了新的工具。
This study evaluated a newly developed swine monoplegic pressure sore model by testing the uniformity of the initial wound size. The natural healing also was evaluated. Nine minipigs were used. The hindlimb was denervated by transecting the unilateral nerve roots L1 through S2. At 5 to 14 days, 800 mmHg of pressure was applied to the denervated skin over the trochanteric area with a 3-cm-diameter disk compressing the skin and subcutaneous tissue against the underlying bone for 48 hours. The wound was then debrided of devascularized tissue. Wound surface areas were calculated from photographs. Wound volumes were obtained by measuring the volume of saline needed to fill the wound defect. Full-thickness sores of uniform size developed in all pigs without mortality or complications. Wound surface area and volume increased initially, peaked, and then decreased in an exponential fashion. This model provides a new tool for direct comparison of pressure sore treatment modalities for short and long-term studies.