COMPARATIVE SUSCEPTIBILITY OF ANAEROBIC BACTERIA TO MINOCYCLINE, DOXYCYCLINE, AND TETRACYCLINE
COMPARATIVE SUSCEPTIBILITY OF ANAEROBIC BACTERIA TO MINOCYCLINE, DOXYCYCLINE, AND TETRACYCLINE
复制标题
DOI：
10.1128/aac.7.1.46
复制
发表时间：
1975-01-01
影响因子：
4.9
通讯作者：
GUZE, LB
中科院分区：
文献类型：
--
作者：
CHOW, AW;PATTEN, V;GUZE, LB
用琼脂稀释法测定了622株临床分离的厌氧菌对米诺环素、强力霉素和四环素的敏感性。除脆弱拟杆菌外，多种其他厌氧菌对可达到的血液浓度的四环素（6.25 μg/ml抑制55%）和强力霉素（2.5 μg/ml抑制58%）具有耐药性。相比之下，米诺环素的活性显著高于多西环素和四环素（P< 0.05），70%的菌株被该抗生素的可达血液浓度（2.5 μg/ml）抑制。米诺环素的增强活性对于解淀粉消化球菌、大型毕赤酵母、普氏毕赤酵母、厌氧消化链霉菌和产黑色素拟杆菌尤其显著。米诺环素对厌氧菌感染的临床疗效的进一步评价是指。
The comparative susceptibility of 622 recent clinical isolates of anaerobic bacteria to minocycline, doxycycline, and tetracycline was determined by an agar-dilution technique. In addition toBacteroides fragilis, a variety of other anaerobic bacteria was resistant to achievable blood concentrations of tetracycline (55% inhibited by 6.25 μg/ml) and doxycycline (58% inhibited by 2.5 μg/ml). In contrast, minocycline was significantly more active (P< 0.05) than both doxycycline and tetracycline, and 70% of strains were inhibited by achievable blood concentrations of this antibiotic (2.5 μg/ml). The enhanced activity of minocycline was particularly striking forPeptococcus asaccharolyticus, P. magnus, P. prevotii, Peptostreptococcus anaerobius, andBacteroides melaninogenicus. Further evaluation of the clinical efficacy of minocycline against anaerobic infections is indicated.