Sleep problems in children with autism spectrum disorders, developmental delays, and typical development: a population-based study
Sleep problems in children with autism spectrum disorders, developmental delays, and typical development: a population-based study
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DOI：
10.1111/j.1365-2869.2008.00650.x
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发表时间：
2008-06-01
影响因子：
4.4
通讯作者：
Hansen, Robin L.
中科院分区：
文献类型：
--
作者：
Krakowiak, Paula;Goodlin-Jones, Beth;Hansen, Robin L.
这项研究比较了2至5岁自闭症谱系障碍（ASD）儿童与其他发育迟缓（DD）和典型发育（TD）儿童的父母报告的睡眠特征。我们纳入了529名儿童（303名ASD [167名男性]，63名DD [46名男性]和163名TD [134名男性]）参加了CHARGE研究，这是一项正在进行的基于人群的病例对照研究。参与者的平均年龄为3.6岁（标准差为0.8岁）。ASD的诊断是通过自闭症诊断访谈-修订版（ADI-R）和自闭症诊断观察表（ADOS）确认的。分别使用马伦早期学习量表（MSEL）和瓦恩兰适应行为量表（VABS）评估认知和适应功能。通过加州出生记录、电话访谈、门诊访视时的医学评估和父母管理的问卷调查确定人口统计学、医学和睡眠史信息。53%的ASD儿童至少有一个频繁的睡眠问题，其次是46%的DD儿童和32%的TD组（P < 0.0001）。探索性因素分析的睡眠历史数据产生了两个因素：睡眠开始的问题和夜醒。与TD组相比，ASD儿童的睡眠开始因子评分略高，夜间觉醒因子评分显著较高。DD儿童的因子评分介于ASD和TD组之间。认知或适应性发展不能预测ASD组睡眠问题的严重程度。
This study compared parent-reported sleep characteristics in 2- to 5-year-old children with autism spectrum disorders (ASD) to children with other developmental delays (DD) and typical development (TD). We included 529 children (303 ASD [167 males], 63 DD [46 males], and 163 TD [134 males]) enrolled in the CHARGE study, an ongoing population-based case-control study. The mean age of participants was 3.6 years (standard deviation, 0.8 years). ASD diagnosis was confirmed with Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedules (ADOS). Cognitive and adaptive functioning was assessed using Mullen Scales of Early Learning (MSEL) and Vineland Adaptive Behavior Scales (VABS), respectively. Demographic, medical and sleep history information were ascertained from California birth records, telephone interview, medical assessments at clinic visit, and parent-administered questionnaires. Fifty-three percent of children with ASD had at least one frequent sleep problem, followed by 46% of children with DD, and 32% of the TD group (P < 0.0001). Exploratory factor analyses of sleep history data yielded two factors: sleep onset problems and night waking. Children with ASD had marginally higher sleep onset factor scores and significantly higher night waking factor scores compared with the TD group. Factor scores for children with DD were intermediate between the ASD and TD groups. Cognitive or adaptive development did not predict severity of sleep problems in the ASD group.