Fungal transposable elements: Generators of diversity and genetic tools
Fungal transposable elements: Generators of diversity and genetic tools
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DOI：
10.1007/bf02966312
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发表时间：
1996-12-01
影响因子：
1.5
通讯作者：
Daboussi, MJ
中科院分区：
文献类型：
--
作者：
Daboussi, MJ
几类转座元件(TES)的代表在广泛的真菌物种中得到了表征。研究表明，这些元素是真菌基因组中古老而普遍存在的成分。这些元件中的一些已经被证明通过几种方式积极地影响基因的结构和功能：插入时基因表达失活，通过切除改变核苷酸序列，以及可能通过诱导广泛的染色体重排。因此，TES产生高度遗传多样性的能力可能在真菌基因组的进化中很重要。TES在遗传学研究中也有许多潜在的应用，包括插入突变和种群指纹，以及物种内和物种之间的基因转移。所有这些遗传方法都是研究分子生物学和真菌物种进化的重要工具，其中许多真菌物种缺乏功能性的性周期。
Representatives of several classes of transposable elements (TEs) have been characterized in a broad range of Fungal species. The studies indicate that these elements are ancient and ubiquitous components of fungal genomes. Some of these elements have been shown to actively affect gene structure and function in several ways: inactivation of gene expression upon insertion, modification of the nucleotide sequence through excision, and probably by inducing extensive chromosomal rearrangements. The ability of TEs to generate a high degree of genetic diversity may therefore be important in the evolution of the fungal genome. TEs also have many potential applications in genetic research, including insertional mutagenesis and population fingerprinting, as well as gene transfer within and between species. All these genetic approaches are important as tools in studies of molecular biology and evolution of Fungal species, many of which lack a functional sexual cycle.