Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid.
Regression of NMU-induced mammary tumors with the combination of melatonin and 9-cis-retinoic acid.
复制标题
联合使用褪黑激素和 9-顺式视黄酸可消退 NMU 诱导的乳腺肿瘤。
DOI：
10.1016/j.canlet.2005.01.005
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发表时间：
2005
期刊：
影响因子：
9.7
通讯作者：
Hill,SM
中科院分区：
文献类型：
--
作者：
Melancon,K;Cheng,Q;Kiefer,TL;Dai,J;Lai,L;Dong,C;Yuan,L;Collins,A;Thiyagarajah,A;Long,S;Hill,SM
褪黑素和9-顺式维甲酸(9cRA)联合应用可显著增加N-亚硝基-N-甲基脲诱发的大鼠乳腺肿瘤的消退。治疗组：对照组(乙醇生理盐水)、9cRA(30 mg/kg/d)、褪黑素500μg/d、褪黑素1000μg/d、褪黑素500μg/d+9cRA、褪黑素1000μg/d+9cRA。接受较低剂量褪黑激素500μg+9cRA治疗的大鼠肿瘤消退程度最大(78%)，其中54%完全消退，TUNEL法观察到凋亡细胞显著增加。此外，褪黑素和9cRA联合应用可显著降低肿瘤的多样性和负担。
A significant increase in tumor regression was induced in N-nitroso-N-methylurea-induced mammary tumors in rats treated with the combination of melatonin and 9-cis-retinoic acid (9cRA). Treatment groups included: control (ethanolic saline), 9cRA (30mg/kg chow/day), melatonin 500μg/day, melatonin 1000μg/day, melatonin 500μg/day+9cRA and melatonin 1000μg/day+9cRA. Rats treated with the lower dose of melatonin 500μg+9cRA show the greatest degree of tumor regression (78%), with 54% undergoing complete regression and a significant increase in apoptotic cells observed by TUNEL Assay. Furthermore, tumor multiplicity and burden were significantly decreased by the combination of melatonin and 9cRA.