A dynamic zone defines interneuron remodeling in the adult neocortex
A dynamic zone defines interneuron remodeling in the adult neocortex
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DOI：
10.1073/pnas.0810149105
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发表时间：
2008-12-16
影响因子：
11.1
通讯作者：
Nedivi, Elly
中科院分区：
文献类型：
--
作者：
Lee, Wei-Chung Allen;Chen, Jerry L.;Nedivi, Elly
结构重塑对成人大脑长期可塑性的贡献尚不清楚。在这里，我们研究了GABA能中间神经元树突动力学的特征，并提取了其在皮质功能和电路可塑性中的潜在作用的线索。我们发现重塑的中间神经元包含在一个“动态区”内，该动态区对应于2/3层的浅层条带，重塑的树突位于该区域的下缘。重塑主要发生在树突域的外围，伴随着新的分枝尖端的增加和收缩。我们进一步表明，树突重塑不是特定的中间神经元类别所固有的。这些数据表明，神经元间重塑不是由遗传谱系预先决定的特征，而是由皮质层流电路强加的。我们的发现与前馈和递归联系对自上而下反馈的动态GABA能调制是一致的，并提示了颗粒上新皮质板层功能可塑性的结构成分。
The contribution of structural remodeling to long-term adult brain plasticity is unclear. Here, we investigate features of GABAergic interneuron dendrite dynamics and extract clues regarding its potential role in cortical function and circuit plasticity. We show that remodeling interneurons are contained within a "dynamic zone" corresponding to a superficial strip of layers 2/3, and remodeling dendrites respect the lower border of this zone. Remodeling occurs primarily at the periphery of dendritic fields with addition and retraction of new branch tips. We further show that dendrite remodeling is not intrinsic to a specific interneuron class. These data suggest that interneuron remodeling is not a feature predetermined by genetic lineage, but rather, it is imposed by cortical laminar circuitry. Our findings are consistent with dynamic GABAergic modulation of feedforward and recurrent connections in response to top-down feedback and suggest a structural component to functional plasticity of supragranular neocortical laminae.