SYSTEMIC AND SUPRASPINAL, BUT NOT SPINAL, OPIATES SUPPRESS ALLODYNIA IN A RAT NEUROPATHIC PAIN MODEL
SYSTEMIC AND SUPRASPINAL, BUT NOT SPINAL, OPIATES SUPPRESS ALLODYNIA IN A RAT NEUROPATHIC PAIN MODEL
复制标题
DOI：
10.1016/0304-3940(95)12034-2
复制
发表时间：
1995-10-20
影响因子：
2.5
通讯作者：
YAKSH, TL
中科院分区：
文献类型：
--
作者：
LEE, YW;CHAPLAN, SR;YAKSH, TL
在Kim和Chung的大鼠神经病理性疼痛模型中，研究了腹腔内（IF）、侧脑室（ICV）和鞘内（IT）阿片类药物的作用。在IP和ICV吗啡后观察到异常性疼痛的剂量依赖性减少，但在IT吗啡、IT或ICV c[D-pen 2 D-pen 5]脑啡肽（DPDPE）（δ激动剂）或IT或ICV U 50488 H（κ激动剂）后未观察到。IP纳洛酮可阻断ICV吗啡的效应，而IT麦角新碱、酚妥拉明和8-磺苯茶碱则不能阻断。在IT、ICV和IT吗啡后观察到僵住症（不动），但这与异常性疼痛的减少无关。因此，IP和ICV吗啡可以通过脊髓上的μ阿片受体而不是脊髓的μ阿片受体来减少触觉异常性疼痛。
The effects of intraperitoneal (IF), intracerebroventricular (ICV) and intrathecal (IT) opiates were studied in the rat neuropathic pain model of Kim and Chung. Dose dependent reduction of allodynia was observed after IP and ICV morphine, but not after IT morphine, IT or ICV c[D-pen2 D-pen5]enkephalin (DPDPE) (delta agonist), or IT or ICV U50488H (kappa agonist). The effects of ICV morphine were blocked by IP naloxone, but not by IT methysergide, phentolamine or 8-sulfophenyltheophylline. Catalepsy (immobility) was observed after IT, ICV and IT morphine but this was not reliably associated with a reduction of allodynia. IP and ICV morphine may thus reduce tactile allodynia via supraspinal, but not spinal, mu opioid receptors.