White blood cell inflammatory markers are associated with depressive symptoms in a longitudinal study of urban adults
White blood cell inflammatory markers are associated with depressive symptoms in a longitudinal study of urban adults
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DOI：
10.1038/tp.2016.180
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发表时间：
2016-09-20
影响因子：
6.8
通讯作者：
Zonderman, A. B.
中科院分区：
文献类型：
--
作者：
Beydoun, M. A.;Beydoun, H. A.;Zonderman, A. B.
总白色血细胞计数（TWBCC）和淋巴细胞（PL）或中性粒细胞（PN）的百分比（%）组成与中年和晚年抑郁症有关，尽管这些炎症标志物和抑郁症状之间的性别特异性时间关系尚不清楚。用两种假设研究了在种族和社会经济上不同的城市成年人的纵向数据中炎症和抑郁症状之间的关联。在假设1中，我们研究了TWBCC、PL和PN与抑郁症状水平从基线到随访的变化之间的关系，并按性别分层。在假设2中，我们通过检验抑郁症状与TWBCC、PL和PN变化的关系来检验反向因果关系。多重线性混合效应回归模型进行检查的假设。参与者（n）和重复观察（n '）的样本量为：假设1（n = 2009; n' = 3501）;假设2（n = 2081; n' = 3560）。在关键发现（假设1）中，在女性中，较高的TWBCC与抑郁症状总评分（gamma（1112）+/- s.e.：+0.81 +/- 0.28，P = 0.003），随着时间的推移，积极情感子域的增长较慢，抑郁情感和躯体抱怨的增长较快。在女性中，躯体主诉的基线评分与低PN呈正相关（γ（01 a）= +1.61 +/- 0.48，P
Total white blood cell count (TWBCC) and percentage (%) composition of lymphocytes (PL) or neutrophils (PN) are linked to mid-and late-life depression, though sex-specific temporal relationships between those inflammatory markers and depressive symptoms remain unclear. The association between inflammation and depressive symptoms in longitudinal data on ethnically and socioeconomically diverse urban adults was examined with two hypotheses. In hypothesis 1, we examined the relationship between TWBCC, PL and PN with change in level of depressive symptoms from baseline to follow-up, stratifying by sex. In hypothesis 2, we examined reverse causality, by testing the relationship of depressive symptoms with change in TWBCC, PL and PN. Multiple linear mixed-effects regression models were performed to examine both the hypotheses. The sample sizes of participants (n) and repeated observations (n') were: Hypothesis 1 (n = 2009; n' = 3501); Hypothesis 2 (n = 2081; n' = 3560). Among key findings (Hypothesis 1), in women, higher TWBCC was linked to a faster increase in depressive symptom total score (gamma(1112)+/- s.e.: +0.81 +/- 0.28, P = 0.003), with a slower increase over time in the positive affect subdomain coupled with faster increases in depressed affect and somatic complaints. Among women, baseline score on somatic complaints was positively associated with low PN (gamma(01a) = +1.61 +/- 0.48, P