Relationship between menarche and fertility in long-tailed macaques (Macaca fascicularis)
Relationship between menarche and fertility in long-tailed macaques (Macaca fascicularis)
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DOI：
10.1262/jrd.2017-164
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发表时间：
2018-08-01
影响因子：
1.8
通讯作者：
Sankai, Tadashi
中科院分区：
文献类型：
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作者：
Kobayashi, Maiko;Koyama, Takamasa;Sankai, Tadashi
我们试图阐明女性生殖长尾猕猴（食蟹猴）。这些猴子有一个非季节性的月经周期，这使得它们适合在包括医学和再生医学在内的各种领域进行研究。我们分析了个体的繁殖数据，包括初潮时间，月经开始规律，和第一次怀孕。这三个事件与雌性长尾猕猴的成熟有关。所有的研究对象都是在筑波灵长类动物研究中心饲养的雌性长尾猕猴。这项研究包括45名女性;我们在她们的生长记录中包括月经时间、男女同居和第一次怀孕。我们从这些记录中提取了与月经初潮、月经开始规律和首次怀孕有关的年龄和体重数据。从初潮到首次怀孕通常需要两年时间，体重增加约500 g（初潮时体重的21%）;很明显，初潮后有显著的身体变化。我们的研究结果表明，雌性猴子在月经初潮时不一定足够成熟，可以怀孕。因此，在生育力方面使用“成熟”一词可能在月经开始规律后更为准确。这就是我们在发展过程中所说的“青春期”。因此，M。食蟹猴是人类青春期动物模型的候选者。
We attempted to elucidate female reproduction in long-tailed macaques (Macaca fascicularis). These monkeys have a non-seasonal menstruation cycle, which makes them suitable subjects for studies in a variety fields including medical science and regenerative medicine. We analyzed individual breeding data including time of menarche, start of regular menstruation, and first pregnancy. These three events are related to the maturation of female long-tailed macaques. All research subjects were female long-tailed macaques bred at the Tsukuba Primate Research Center. The study comprised 45 females; we included time of menstruation, male-female cohabitation, and first pregnancy in their growth records. We extracted age and weight data relating to menarche, start of regular menstruation, and first pregnancy from these records. In the two years typically required from menarche to first pregnancy, the body weight increased by approximately 500 g (21% of the weight at menarche); it is clear that there is a significant physical change after menarche. Our findings suggest that female monkeys are not necessarily mature enough for pregnancy at menarche. Therefore, the use of the word "maturity" in terms of fecundity may be more accurate after the start of regular menstruation. This is what we term "adolescence" in the developmental process. Therefore, M. fascicularis monkeys are candidates for an animal model of human adolescence.