Dextran-Based Self-Healing Hydrogels Formed by Reversible Diels-Alder Reaction under Physiological Conditions
Dextran-Based Self-Healing Hydrogels Formed by Reversible Diels-Alder Reaction under Physiological Conditions
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在生理条件下通过可逆狄尔斯-阿尔德反应形成的基于葡聚糖的自修复水凝胶。
DOI：
10.1002/marc.201300494
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发表时间：
2013-09-01
影响因子：
4.6
通讯作者：
Chen, Yong Mei
中科院分区：
文献类型：
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作者：
Wei, Zhao;Yang, Jian Hai;Chen, Yong Mei
在生理条件下通过可逆Diels-Alder反应制备了一种葡聚糖基自修复水凝胶。使用细胞相容性富烯改性的葡聚糖作为主要聚合物链和二氯马来酸改性的聚（乙二醇）作为交联剂。宏观和微观观察以及流变学恢复测试都证实了葡聚糖-1-聚（乙二醇）水凝胶的自修复性质（“1”表示“连接”）。此外，扫描电化学显微镜是用于定性和定量原位跟踪水凝胶的自愈合过程的第一次。发现水凝胶表面纵向划痕深度在37 °C下7 h后几乎完全愈合。本工作为制备多糖自修复水凝胶提供了一种简便的方法，该方法可用于多种生物医学领域。
A dextran-based self-healing hydrogel is prepared by reversible Diels-Alder reaction under physiological conditions. Cytocompatible fulvene-modified dextran as main polymer chains and dichloromaleic-acid-modified poly(ethylene glycol) as cross-linkers are used. Both macro- and microscopic observation as well as the rheological recovery test confirm the self-healing property of the dextran-l-poly(ethylene glycol) hydrogels ("l" means "linked-by"). In addition, scanning electrochemical microscopy is used to qualitatively and quantitatively in situ track the self-healing process of the hydrogel for the first time. It is found that the longitudinal depth of scratch on hydrogel surface almost completely healed at 37 °C after 7 h. This work represents a facile approach for fabrication of polysaccharide self-healing hydrogel, which can be potentially used in several biomedical fields.