Effect of indomethacin on swelling, lymphocyte influx, and cartilage proteoglycan depletion in experimental arthritis.
Effect of indomethacin on swelling, lymphocyte influx, and cartilage proteoglycan depletion in experimental arthritis.
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吲哚美辛对实验性关节炎肿胀、淋巴细胞流入和软骨蛋白聚糖消耗的影响。
DOI：
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发表时间：
1989
影响因子：
27.4
通讯作者：
G. A. Higgs
中科院分区：
文献类型：
--
作者：
E. Pettipher;B. Henderson;J. Edwards;G. A. Higgs
本文研究了吲哚美辛对兔抗原性关节炎的影响。关节腔内注射抗原诱导致敏兔膝关节关节炎。在抗原攻击后14天测量关节肿胀，并在第1、7或14天处死动物以收集滑液和组织。消炎痛(1 mg/kg，每日三次)可减少关节肿胀和滑液中前列腺素E_2的浓度。此外，消炎痛还增加了关节软骨蛋白多糖的丢失和炎症滑膜中淋巴细胞的数量。这些发现表明，消炎痛和相关药物对炎性关节炎的症状改善可能是以对关节组织的显著不良影响为代价的。
The effects of indomethacin on antigen induced arthritis in rabbits have been investigated. Arthritis was induced in the knee joints of sensitised rabbits by intra-articular injection of antigen. Swelling of the joints was measured for 14 days after antigen challenge, and groups of animals were killed on days 1, 7, or 14 for collection of synovial fluids and tissues. Indomethacin (1 mg/kg, three times daily) reduced joint swelling and the prostaglandin E2 concentrations in synovial fluid. In addition, indomethacin increased the loss of proteoglycan from articular cartilage and the numbers of lymphocytes in the inflamed synovial lining. These findings suggest that the symptomatic benefits of indomethacin and related drugs in inflammatory arthritis may be achieved at the expense of significant adverse effects on joint tissues.
影响因子：
4.4
作者：
S. Kunkel;S. Chensue;S. Phan
通讯作者：
S. Kunkel;S. Chensue;S. Phan