LV functional evaluation on 11C-PiB PET/CT in cardiac amyloidosis
LV functional evaluation on 11C-PiB PET/CT in cardiac amyloidosis
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11C-PiB PET/CT 评价心脏淀粉样变性的左室功能
DOI：
10.1007/s12350-022-02966-x
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发表时间：
2022
影响因子：
2.4
通讯作者：
Nishiyama Yoshihiro
中科院分区：
文献类型：
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作者：
Miyatake Misaki;Norikane Takashi;Imajo Masashi;Takami Yasukage;Mitamura Katsuya;Yamamoto Yuka;Maeda Yukito;Noma Takahisa;Nishiyama Yoshihiro
心脏淀粉样变性（CA）导致限制性心肌病，由心肌中异常蛋白质产物淀粉样蛋白的细胞外沉积引起。虽然CA的患病率正在增加，但它曾被认为是一种罕见疾病。11 C-Pittsburgh compound B（11 C-PiB）是硫磺素T的衍生物，是一种特异性强、有应用前景的CA正电子发射断层显像（PET）示踪剂。1-4本病例强调了动态11 C-PiB PET在CA左心室功能检查中的潜在效用。
Cardiac amyloidosis (CA) leads to restrictive cardiomyopathy, caused by the extracellular deposition of an abnormal protein product, amyloids, in the myocardium. Although the prevalence of CA is increasing, it was once considered a rare disease. 11C-Pittsburgh compound B (11C-PiB), a derivative of thioflavin T, is a specific and promising positron emission tomography (PET) tracer for the diagnosis of CA. 1–4 The present case highlights the potential utility of dynamic 11C-PiB PET for the examination of left ventricular function in CA.