Quality of life scores differed according to mode of administration in a review of three major oncology questionnaires
Quality of life scores differed according to mode of administration in a review of three major oncology questionnaires
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DOI：
10.1016/j.jclinepi.2005.06.011
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发表时间：
2006-02-01
影响因子：
7.2
通讯作者：
Wee, J
中科院分区：
文献类型：
--
作者：
Cheung, YB;Goh, C;Wee, J
目的：评估肿瘤学中三个主要生活质量问卷（FACT-G、FLIC和EORTC QLQ-C30）的评分是否与现实临床研究环境中的给药模式相关。研究设计和设置：在新加坡招募了1，265例癌症患者的异质性样本。大约四分之一的患者选择由研究人员进行访谈;其余的患者自行完成问卷。多元回归用于调整患者之间人口统计学和临床特征的差异。一个等效的利润率被定义为0.25标准deviations.Results：除了一个例外（EORTC QLQ-C30全球功能量表），所有的规模显示较高的平均值，在接受采访的患者比患者谁自我管理的问卷调查。对于FACT-G的身体和功能健康量表以及EORTC QLQ-C30的身体和社会功能量表，差异很小，置信区间完全在等效区内。FACT-G的情绪健康评分在不同给药模式下不同，置信区间超出等效区。有没有互动的管理模式和受访者的教育level.Conclusion：身体方面的生活质量是不敏感的面试官管理，但心理方面。建议对某些比额表进行统计调整。(c)2006爱思唯尔公司All rights reserved.
Objective: To assess whether scores on the three major quality-of-life questionnaires in oncology (FACT-G, FLIC, and EORTC QLQ-C30) are associated with modes of administration in a realistic clinical research setting.Study Design and Setting: A heterogeneous sample of 1,265 cancer patients was recruited in Singapore. About one-fourth of the patients chose to have the interview administered by research staff; the rest self-completed the questionnaires. Multiple regression was used to adjust for differences in demographic and clinical characteristics between patients. An equivalence margin was defined as 0.25 standard deviations.Results: Apart from one exception (the EORTC QLQ-C30 global functioning scale), all scales showed higher mean values in patients who were interviewed than patients who self-administered the questionnaires. For the physical and functional well-being scales of FACT-G and the physical and social functioning scales of EORTC QLQ-C30, the differences were small and the confidence intervals fell totally within the equivalence zone. The emotional well-being score of the FACT-G was different across modes of administration and the confidence interval fell outside the equivalence zones. There was no interaction between modes of administration and respondents' education level.Conclusion: The physical aspect of quality-of-life is not sensitive to interviewer administration but the psychological aspect is. Statistical adjustment for some scales is recommended. (c) 2006 Elsevier Inc. All rights reserved.