Correlation in rheumatoid arthritis of concentrations of plasma C3d, serum rheumatoid factor, immune complexes and C-reactive protein with each other and with clinical features of disease activity.
Correlation in rheumatoid arthritis of concentrations of plasma C3d, serum rheumatoid factor, immune complexes and C-reactive protein with each other and with clinical features of disease activity.
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类风湿性关节炎中血浆 C3d、血清类风湿因子、免疫复合物和 C 反应蛋白浓度的相互关系以及与疾病活动性临床特征的相关性。
DOI：
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发表时间：
1982
影响因子：
4.6
通讯作者：
M. B. Pepys
中科院分区：
文献类型：
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作者：
R. Mallya;D. Vergani;D. Tee;L. Bevis;F. C. D. Beer;Hedley Berry;E. Hamilton;B. Mace;M. B. Pepys
测量了 99 名类风湿性关节炎患者的血浆中 C3d 浓度以及血清中 C 反应蛋白 (CRP)、免疫复合物和类风湿因子的浓度。大多数患者的水平升高，其值与根据新描述的指数评估的疾病活动性相关，该指数基于疾病的主观、半客观和客观特征的多变量分析。血浆C3d与循环免疫复合物、免疫复合物与类风湿因子、血清CRP与免疫复合物、血清CRP与血浆C3d的值之间也存在显着相关性。血浆 C3d 的测量提供了检测体内补体激活的有用方法，补体激活可能与类风湿性关节炎的发病机制有关，但 C3d 水平或任何其他变量都不像血清 CRP 浓度那样与疾病活动密切相关。
The concentrations of C3d in the plasma and of C-reactive protein (CRP), immune complexes and rheumatoid factor in the serum were measured in 99 patients with rheumatoid arthritis. Most patients had raised levels, the values of which correlated with disease activity assessed according to a newly described index based on multivariate analysis of subjective, semi-objective and objective features of the disease. There were also significant correlations between the values for plasma C3d and circulating immune complexes, immune complexes and rheumatoid factor, serum CRP and immune complexes, and serum CRP and plasma C3d. Measurement of plasma C3d provides a useful means of detecting in vivo complement activation, which may be involved in the pathogenesis of rheumatoid arthritis, but neither C3d levels nor any of the other variables correlated as closely with disease activity as did the serum CRP concentration.