Lack of liver steatosis in germ-free mice following hypercaloric diets
Lack of liver steatosis in germ-free mice following hypercaloric diets
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DOI：
10.1007/s00394-018-1748-4
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发表时间：
2019-08-01
影响因子：
5
通讯作者：
Bischoff, Stephan C.
中科院分区：
文献类型：
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作者：
Kaden-Volynets, Valentina;Basic, Marijana;Bischoff, Stephan C.
目的过度喂养引起的实验性肝脂肪变性与肠道通透性增强和内毒素向肝脏转运有关。我们通过在常规和无菌（GF）饲养的小鼠中进行喂养实验，研究了肠道微生物群在脂肪变性形成中的作用。方法分别饲喂西式饲粮（WSD）和对照饲粮（CD） 8周，对照饲粮中添加液体果糖(F)或不添加。干预后测量肝脏脂肪变性和肠通透性指标。结果饲喂WSD的小鼠体重明显高于饲喂CD的小鼠(p
Purpose Experimental liver steatosis induced by overfeeding is associated with enhanced gut permeability and endotoxin translocation to the liver. We examined the role of the gut microbiota for steatosis formation by performing the feeding experiments in mice raised under conventional and germ-free (GF) housing.Methods Adult wild-type and GF mice were fed a Western-style diet (WSD) or a control diet (CD), the latter combined with liquid fructose supplementation (F) or not, for 8 weeks. Markers of liver steatosis and gut permeability were measured after intervention.Results Mice fed a WSD increased body weight compared to those fed a CD (p