PANTOTHENIC ACID DEFICIENCY INDUCED IN HUMAN SUBJECTS
PANTOTHENIC ACID DEFICIENCY INDUCED IN HUMAN SUBJECTS
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DOI：
10.1172/jci103156
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发表时间：
1955-01-01
影响因子：
15.9
通讯作者：
DAUM, K
中科院分区：
文献类型：
--
作者：
BEAN, WB;HODGES, RE;DAUM, K
Bean和Hodges（1）给出了一份关于4名年轻男性的初步报告，他们的临床疾病和代谢缺陷是由缺乏泛酸的”饮食”和ω-甲基泛酸（一种维生素拮抗剂）引起的（图1）。这里建议描述实验的细节、结果和一些解释。在人类营养中使用分子拮抗剂（2，3）的背景以前已经使用烟酸拮抗剂（4）进行了探索。在公认的B族维生素中，泛酸在人体营养中一直是最令人困惑的。威廉姆斯、莱曼、固特异、特鲁斯代尔和霍尔登发现了它（5），并发现它存在于辅酶A中（6），这表明它在人体中具有代谢功能，但它在治疗营养不良者方面的应用却没有任何线索。来自实验动物的数据显示，其缺乏的主要表现是肾上腺皮质功能衰竭，伴有低血浆胆固醇、胃肠道症状和病变、抗体产生受损、神经病变和表皮改变（7-11）。泛酸在动物中的功能已经由Drell、Dunn及其同事（12-15）阐明，他们合成了ω-甲基泛酸，证明其拮抗泛酸，测定了其在动物中的毒性，并表明其有害作用可以被泛酸逆转或预防。其中一些观察结果得到了验证，并由Shils（16）扩展。
Bean and Hodges (1) gave a preliminary report of four young men in whom clinical disorders and metabolic faults were induced by a" diet" devoid of pantothenic acid, with omega-methylpanto-thenic acid, a vitamin antagonist (Figure 1). It is proposed here to describe details of the experi-ments, results, and some interpretations. The background for using molecular antagonists (2, 3) in human nutrition had been explored previously using antagonists to nicotinic acid (4). Among the accepted B-complex vitamins, pantothenic acid has been most puzzling in human nu-trition. Its discovery by Williams, Lyman, Goodyear, Truesdail, and Holaday (5) and its presence in coenzyme A (6) suggested metabolic functions in man. Its employment in treating undernourished persons yielded no clue. Data from experi-mental animals revealed that the principal manifestations of its deficiency are those ofadrenal cortical failure, accompanied by low plasma cholesterol, gastrointestinal symptoms and lesions, impaired antibody production, neurological lesions and alterations of the epidermis (7-11). The function of pantothenic acid in animals has been clarified by Drell, Dunn and their co-workers (12-15) who synthesized omega-methylpantothenic acid, demonstrated that it antagonized pantothenic acid, determined its toxicity in animals and showed that its deleterious effects could be reversed or prevented by pantothenic acid. Some of these observations were verified and extended by Shils (16).