Basal and glucose- and arginine-stimulated serum concentrations of insulin, C-peptide, and glucagon in hyperthyroid patients.
Basal and glucose- and arginine-stimulated serum concentrations of insulin, C-peptide, and glucagon in hyperthyroid patients.
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甲状腺功能亢进患者的基础和葡萄糖和精氨酸刺激的胰岛素、C 肽和胰高血糖素血清浓度。
DOI：
10.1016/0026-0495(86)90151-4
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Pezzarossa,A
中科院分区：
文献类型：
--
作者：
Roti,E;Braverman,LE;Robuschi,G;Salvi,M;Gardini,E;d'Amato,L;Maestri,D;Montermini,M;Borciani,E;Pezzarossa,A
研究了16例甲状腺功能亢进型Graves病患者和10例甲状腺功能正常、年龄和性别匹配的正常人口服葡萄糖和精氨酸输注对血糖、胰高血糖素、血清胰岛素和c肽浓度的影响。甲状腺功能亢进患者的基础血浆葡萄糖浓度明显较高，但两组在葡萄糖和精氨酸给药后的血浆葡萄糖反应相似。甲状腺机能亢进者和正常人在葡萄糖给药后胰岛素反应相似，而甲状腺机能亢进者在精氨酸输注期间胰岛素反应明显降低。甲亢患者血清c肽对葡萄糖和精氨酸的反应明显减弱，血浆胰高血糖素对精氨酸输注的反应降低。这些结果表明，通过口服葡萄糖和精氨酸输注后的c肽和胰高血糖素分泌来评估，甲状腺机能亢进患者胰腺β和α细胞分泌功能受损。葡萄糖给药后甲亢患者c肽与胰岛素分泌明显差异可能是由于肝脏胰岛素提取减少或c肽代谢增强所致。
The effect of oral glucose and arginine infusion on plasma glucose, glucagon, serum insulin, and C-peptide concentrations was evaluated in 16 patients with hyperthyroid Graves' disease and in ten euthyroid age- and sex-matched normal subjects. Basal plasma glucose concentrations were significantly higher in the hyperthyroid patients, but the plasma glucose response following glucose and arginine administration was similar in the two groups. The insulin response was similar in the hyperthyroid and normal subjects after glucose administration and significantly lower during arginine infusion in the hyperthyroid patients. The serum C-peptide response to both glucose and arginine administration was markedly blunted in the hyperthyroid patients, and the plasma glucagon response to arginine infusion was decreased. These results suggest that pancreatic beta and alpha cell secretory function is impaired in hyperthyroidism as assessed by C-peptide and glucagon secretion following oral glucose administration and arginine infusion. The apparent discrepancy between C-peptide and insulin secretion in the hyperthyroid patients following glucose administration might be due to diminished hepatic extraction of insulin or enhanced metabolism of C-peptide.