Newly discovered roles for basophils: a neglected minority gains new respect
Newly discovered roles for basophils: a neglected minority gains new respect
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DOI：
10.1038/nri2458
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发表时间：
2009-01-01
影响因子：
100.3
通讯作者：
Obata, Kazushige
中科院分区：
文献类型：
--
作者：
Karasuyama, Hajime;Mukai, Kaori;Obata, Kazushige
嗜碱性粒细胞是最不常见的粒细胞类型，占外周血白细胞的比例不到1%。由于嗜碱性粒细胞的少数地位和与肥大细胞相似的表型，在免疫学研究中经常被忽视，或者被认为在体内的免疫反应中具有次要的、多余的作用。然而，最近的研究已经明确了嗜碱性粒细胞在免疫调节和过敏反应中的作用，并表明嗜碱性粒细胞和肥大细胞在免疫反应中具有不同的作用。
Basophils are the least common type of granulocyte and they account for less than 1% of peripheral blood leukocytes. Because of this minority status and a phenotype that is similar to mast cells, basophils have often been neglected in immunological studies or considered to have minor, redundant roles in immune responses in vivo. However, recent studies have now defined previously unrecognized roles for basophils in both immune regulation and allergic responses, and have shown that basophils and mast cells have distinct roles in immune responses.