Nanostructured hydrogels for three-dimensional cell culture through self-assembly of fluorenylmethoxycarbonyl-dipeptides
Nanostructured hydrogels for three-dimensional cell culture through self-assembly of fluorenylmethoxycarbonyl-dipeptides
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DOI：
10.1002/adma.200501522
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发表时间：
2006-03-03
影响因子：
29.4
通讯作者：
Ulijn, RV
中科院分区：
文献类型：
--
作者：
Jayawarna, V;Ali, M;Ulijn, RV
许多短肽两亲物由连接到芴甲氧羰基的二肽组成，在生理条件下自发形成纤维状水凝胶（见图）。这些凝胶的结构和物理性质由肽结构单元的氨基酸序列决定，并且凝胶支持软骨细胞的三维细胞培养。
A number of short peptide amphiphiles consisting of dipeptides linked to fluorenylmethoxycarbonyl spontaneously form fibrous hydrogels under physiological conditions (see figure). The structural and physical properties of these gels are dictated by the amino acid sequence of the peptide building blocks, and the gels support the three-dimensional cell culture of chondrocytes.