Infection prevention in acute nonlymphocytic leukemia. Laminar air flow room reverse isolation with oral, nonabsorbable antibiotic prophylaxis.
Infection prevention in acute nonlymphocytic leukemia. Laminar air flow room reverse isolation with oral, nonabsorbable antibiotic prophylaxis.
复制标题
急性非淋巴细胞白血病的感染预防。
DOI：
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发表时间：
1975
影响因子：
39.2
通讯作者：
P. Wiernik
中科院分区：
文献类型：
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作者：
S. Schimpff;W. Greene;V. M. Young;C. Fortner;N. Cusack;J. Block;P. Wiernik
对64例连续入院接受缓解诱导的非感染急性非淋巴细胞白血病成人患者进行反向分离和预防性口服不可吸收抗生素的评估。患者被随机分配到层流病房反向隔离，口服不可吸收抗生素（LAF + A），常规医院病房护理抗生素（W + A），或单独病房护理(W)。LAF + A组患者总感染、菌血症、肺炎、直肠脓肿、尿路感染和咽炎的发生率显著降低。LAF + A组感染死亡率降低，首次感染或致死性感染时间延迟。定期服用抗生素的W + A组患者感染的减少与LAF + A组患者相似，但不能耐受抗生素的患者感染的发生率与病房患者相当。LAF + A组和W + A组患者也比无保护病房患者有更高的完全缓解率和更长中位生存期。
Reverse isolation and prophylactic oral nonabsorbable antibiotics were evaluated among 64 consecutive noninfected adults with acute nonlymphocytic leukemia admitted for remission induction. Patients were randomly allocated to laminar air flow room reverse isolation with oral nonabsorbable antibiotics (LAF plus A), routine hospital ward care with antibiotics (W plus A), or ward care alone (W). The LAF plus A patients had a significantly decreased incidence of total infection, bacteremias, pneumonias, rectal abscesses, urinary tract infection, and pharyngitis. Infectious deaths were reduced in the LAF plus A group and the time to the first infection or to fatal infection was delayed. The W plus A patients who regularly ingested the antibiotics had a reduction in infections similar to that of the LAF plus A patients but those who could not tolerate the antibiotics had an incidence of infection comparable to the ward patients. The LAF plus A and the W plus A patients also had higher complete remission rates and longer median survival than the unprotected ward patients.