Herpes simplex virus and pterygium in Taiwan
Herpes simplex virus and pterygium in Taiwan
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DOI：
10.1097/ico.0b013e31815ca667
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发表时间：
2008-04-01
期刊：
影响因子：
2.8
通讯作者：
Lin, Ken-Kuo
中科院分区：
文献类型：
--
作者：
Chen, Yeong-Fong;Hsiao, Ching-Hsi;Lin, Ken-Kuo
目的：评估翼状胬肉中是否存在单纯疱疹病毒（HSV），以研究翼状胬肉高发的热带国家台湾HSV与翼状胬肉之间可能的关联。方法：获得65例翼状胬肉、10例正常结膜、8例结膜痣和2例恶性结膜黑色素瘤。记录每位患者的临床病史。 HSV 检测是通过病毒序列的聚合酶链反应扩增来完成的。 HSV 阳性样本随后进行 DNA 原位杂交。对结果进行统计分析。结果：通过聚合酶链反应，在3例（5%）翼状胬肉中检出HSV，结膜对照未显示HSV。所有3例HSV阳性翼状胬肉研究均为DNA原位杂交阴性。翼状胬肉与HSV的存在之间没有统计学上显着的相关性。结论：HSV与台湾翼状胬肉的形成无关；翼状胬肉的发病机制尚不完全清楚。
Purpose: To evaluate the presence of herpes simplex virus (HSV) in pterygia to study the possible association between HSV and pterygia in Taiwan, a tropical country with a high prevalence of pterygium.Methods: Sixty-five pterygia, 10 normal conjunctiva, 8 conjunctival nevi, and 2 malignant conjunctival melanomas were obtained. Clinical histories were recorded for each patient. HSV detection was accomplished by polymerase chain reaction amplification of viral sequences. HSV-positive specimens underwent subsequent DNA in situ hybridization. Results were statistically analyzed.Results: By using polymerase chain reaction, HSV was detected ill 3 (5%) pterygia, and no Conjunctival control displayed HSV All 3 HSV-positive pterygia studies were DNA in situ hybridization negative. There was no statistically significant correlation between pterygium and the presence of HSV.Conclusions: HSV is not associated with pterygium formation in Taiwan; the pathogenesis of pterygia is still incompletely understood.