Serial cytokine alterations and abnormal neuroimaging in newborn infants with encephalopathy
Serial cytokine alterations and abnormal neuroimaging in newborn infants with encephalopathy
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DOI：
10.1111/apa.13745
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发表时间：
2017-04-01
期刊：
影响因子：
3.8
通讯作者：
Molloy, Eleanor J.
中科院分区：
文献类型：
--
作者：
O'Hare, Fiona M.;Watson, R. William G.;Molloy, Eleanor J.
目的：炎症细胞因子可能在实验性缺氧缺血性脑损伤的最终共同通路中发挥作用。我们的目的是配置文件的全身促炎和抗炎反应，在第一周的生命中，在第三次转诊大学新生儿重症监护病房，系列血液样本进行了分析，从41个足月婴儿（出生时需要复苏）在这个前瞻性的观察性试点研究。检测10种促炎和抗炎细胞因子的血清水平，包括白细胞介素（IL）-1、IL-1、IL-6、IL-8、IL-10、肿瘤坏死因子（TNF）-、干扰素（IFN）-、血管内皮生长因子（VEGF）、粒细胞/集落刺激因子（G-CSF）和粒细胞巨噬细胞/集落刺激因子（GM-CSF）。新生儿脑病和神经影像学异常的婴儿（n = 15）在0-24 h的粒细胞-巨噬细胞/集落刺激因子和24-48 h的白细胞介素-8，白细胞介素-6和白细胞介素-10显著升高。肿瘤坏死因子和血管内皮生长因子水平在72-96小时较低（p < 0.05）。白细胞介素-10水平显着升高与mortals.Conclusion：血清细胞因子的变化和先天免疫失调的第一周的生活可能是新生儿脑病的结果指标，但需要在更大的研究验证。
Aim: Inflammatory cytokines may play a role in the final common pathway in the pathogenesis of hypoxic-ischaemic injury in experimental models. We aimed to profile the systemic pro-and anti-inflammatory response over the first week of life in term infants at risk of neonatal encephalopathy.Method: In a tertiary referral university neonatal intensive care unit, serial blood samples were analysed from 41 term infants (requiring resuscitation at birth) in this prospective observational pilot study. Serum levels of 10 pro-and anti-inflammatory cytokines were evaluated including interleukin(IL)-1, IL-1, IL-6, IL-8, IL-10, tumour necrosis factor(TNF)-, interferon (IFN)-, vascular endothelial growth factor (VEGF), granulocyte/colony-stimulating factor (G-CSF) and granulocyte macrophage/colony-stimulating factor (GM-CSF).Results: Infants with neonatal encephalopathy and abnormal neuroimaging (n = 15) had significantly elevated granulocyte macrophage/colony-stimulating factor at 0-24 h and interleukin-8, interleukin-6 and interleukin-10 at 24-48 hour. Tumour necrosis factor- and vascular endothelial growth factor levels were lower at 72-96 hour (p < 0.05). Significantly elevated levels of interleukin-10 were associated with mortality.Conclusion: Serum cytokine changes and innate immune dysregulation in the first week of life may be indicators of outcome in neonatal encephalopathy but require validation in larger studies.