NATURAL-HISTORY OF PREMATURE PUBARCHE - AN AUXOLOGICAL STUDY
NATURAL-HISTORY OF PREMATURE PUBARCHE - AN AUXOLOGICAL STUDY
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DOI：
10.1210/jc.74.2.254
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发表时间：
1992-02-01
影响因子：
5.8
通讯作者：
VICENSCALVET, E
中科院分区：
文献类型：
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作者：
IBANEZ, L;VIRDIS, R;VICENSCALVET, E
据报道，青春期过早发育的女孩的自然史是正常的，但对青春期和最终身高的影响没有很好的记录。我们评估了一组女孩的结果与过早的阴毛从两个拉丁美洲人口中的21-羟化酶缺乏症已被排除的促肾上腺皮质激素测试。患者包括127名女孩（70名意大利北部和57名西班牙北部），其中69名已进入青春期，38名已达到成人身高。对身高、骨龄、青春期的开始和进展、身高预后、成年身高和基线血浆雄激素水平进行了评估。在随访的第一年，骨骼成熟和高大身材是恒定的特征，随后下降。青春期开始于9.7 +/- 0.9岁，初潮年龄（12.0 +/- 1.0岁）与母亲和人群初潮年龄相当。两个人群的青春期里程碑的外观和时间表非常相似。成人身高与诊断时和青春期开始时的身高预后相关，且均高于双亲身高。阴毛早长可短暂加速生长和骨成熟，对青春期的开始和进展以及最终身高无负面影响。
The natural history of girls with premature pubarche is reported to be normal, but the effects on puberty and on final height are not well documented. We assessed the outcome of a group of girls with premature pubarche from two Latin populations in whom 21-hydroxylase deficiency had been ruled out by an ACTH test. Patients comprised 127 girls (70 Northern-Italian and 57 Northern-Spanish), of whom 69 had entered puberty and 38 had attained adult height. Height, bone age, onset and progression of puberty, height prognosis, adult height, and baseline plasma androgen levels were evaluated.Advanced skeletal maturation and tall stature were constant features during the first years of follow-up and subsequently declined. Puberty began at 9.7 +/- 0.9 yr, and age at menarche (12.0 +/- 1.0 yr) was comparable to maternal and population menarcheal ages. The appearance and chronology of pubertal milestones in both populations were very similar. Adult heights correlated with the height prognosis at diagnosis and at onset of puberty, and were above midparental heights.Premature pubarche produces a transient acceleration in growth and bone maturation with no negative effects on the onset and progression of puberty and final height.