Structure and biological properties of mixed-ligand Cu(II) Schiff base complexes as potential anticancer agents
Structure and biological properties of mixed-ligand Cu(II) Schiff base complexes as potential anticancer agents
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混合配体 Cu(II) 希夫碱配合物作为潜在抗癌剂的结构和生物学特性
DOI：
10.1016/j.ejmech.2017.04.026
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发表时间：
2017-07-07
影响因子：
6.7
通讯作者：
Yang, Feng
中科院分区：
文献类型：
--
作者：
Gou, Yi;Li, Jinlong;Yang, Feng
We synthesized two mixed-ligand Cu(II) complexes containing different aroylhydrazone ligands and a pyridine co-ligand, namely, [Cu(L1)(Py)] (Cl) and [Cu(L2)(Py)(Br)] (C2) (L1 = (E)-2-hydroxy-W-((2-hydroxynaphthalen-1-yl)methylene)benzohydrazide, Py = pyridine, L2 = (E)-2-hydroxy-W-(phenyl(pyridin-2-yl)methylene)benzohydrazide), and assessed their chemical and biological properties to understand their marked activity. C2 showed better anticancer activity than Cl in various human cancer cell lines, including the cisplatin-resistant lung cancer cell line A549cisR. Both Cu(II) complexes, especially C2, displayed promising anti-metastatic activity against HepG2 cells. Spectroscopic titration and agarose gel electrophoresis experiments indicated that C2 exhibited binding affinity toward calf-thymus DNA and efficient pBR322 DNA-cleaving ability. Further mechanistic studies showed that C2 effectively induced DNA damage and thus led to cell cycle arrest at the G2/M phase, and also stimulated mitochondrial dysfunction mediated by reactive oxygen species and caspase-dependent apoptosis. (C) 2017 Elsevier Masson SAS. All rights reserved.
