Phase synchronization of the ongoing EEG and auditory EP generation
Phase synchronization of the ongoing EEG and auditory EP generation
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DOI：
10.1016/s1388-2457(02)00327-9
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发表时间：
2003-01-01
影响因子：
4.7
通讯作者：
Boutros, NN
中科院分区：
文献类型：
--
作者：
Jansen, BH;Agarwal, G;Boutros, NN
目的：我们研究了自发脑电（EEG）相位同步在健康个体听觉诱发电位（EP）产生中的作用。方法：20名健康受试者在双刺激模式下，使用两个相同的纯音（SI和S2）间隔0.5 s，获得听觉反应。单次听觉诱发电位分解成正弦，指数衰减/增加的成分，使用分段Prony方法（PPM）。前和刺激后的相位直方图进行比较，以确定由听觉stimulation.Results产生的相位同步的程度：单响应分析显示，S1刺激产生的相位同步在2-8 Hz的频率范围内，很少或没有伴随的幅度增加。一个显着减少的相位效应被认为是在响应S2 stimulation.Conclusions：刺激诱导的相位同步的进行中的EEG是一个主要的机制产生的听觉EP成分的潜伏期在50-250 ms的范围。这里访问的EP分量是通过相位同步生成的，这一事实意味着整体平均EP将不类似于单个试验响应，并且将单个试验响应视为总体平均值的幅度缩放版本肯定是误导性的。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Objective: We investigated the role of phase synchronization of the spontaneous electroencephalogram (EEG) in auditory evoked potential (EP) generation in a sample of healthy individuals.Methods: Auditory responses were obtained from 20 healthy subjects following a double stimulus paradigm, using two identical tone bursts (SI and S2) separated by 0.5 s. Single-trial auditory evoked potentials were decomposed into sinusoidal, exponentially decaying/ increasing components using the piecewise Prony method (PPM). Pre- and post-stimulus phase histograms were compared to determine the degree of phase synchronization produced by auditory stimulation.Results: Analysis of single responses revealed that the S1 stimuli produced phase synchronization in the 2-8 Hz frequency range, with little or no concomitant amplitude increase. A significantly reduced phase effect was seen in response to S2 stimuli.Conclusions: Stimulus-induced phase synchronization of the ongoing EEG is a major mechanism for the generation of auditory EP components with a latency in the 50-250 ms range.Significance: The fact that the EP components accessed here are generated through phase synchronization implies that the ensemble-averaged EP will not resemble the single trial response, and it would certainly be misleading to consider the single trial response as an amplitude-scaled version of the ensemble average. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.