Epigenetic changes in inflammatory and autoimmune diseases.
Epigenetic changes in inflammatory and autoimmune diseases.
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DOI：
10.1007/978-94-007-4525-4_20
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发表时间：
2013-01-01
影响因子：
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通讯作者：
Tost, Jorg
中科院分区：
文献类型：
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作者：
Nielsen, Helene Myrtue;Tost, Jorg
在高等真核生物中，表观遗传修饰对于正确的染色质折叠和基因表达的正确调控至关重要。在过去的几年中，异常表观遗传修饰在炎症和自身免疫性疾病中的参与已经被认识到并引起了极大的兴趣。然而，不同疾病表型的表观遗传机制仍然知之甚少。由于自身免疫性疾病和炎症性疾病至少部分是T细胞介导的，我们将在本章中介绍T细胞分化的表观遗传学，然后总结功能失调的T细胞在各种疾病（如1型糖尿病、类风湿性关节炎、系统性红斑狼疮、多发性硬化症、炎症性肠病和哮喘）中显示的异常表观遗传修饰的现有知识。
In higher eukaryotic organisms epigenetic modifications are crucial for proper chromatin folding and thereby proper regulation of gene expression. In the last years the involvement of aberrant epigenetic modifications in inflammatory and autoimmune diseases has been recognized and attracted significant interest. However, the epigenetic mechanisms underlying the different disease phenotypes are still poorly understood. As autoimmune and inflammatory diseases are at least partly T cell mediated, we will provide in this chapter an introduction to the epigenetics of T cell differentiation followed by a summary of the current knowledge on aberrant epigenetic modifications that dysfunctional T cells display in various diseases such as type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease, and asthma.