Disorders of "taste cognition" are associated with insular involvement in patients with Alzheimer's disease and vascular dementia: "memory of food is impaired in dementia and responsible for poor diet".
Disorders of "taste cognition" are associated with insular involvement in patients with Alzheimer's disease and vascular dementia: "memory of food is impaired in dementia and responsible for poor diet".
复制标题
“味觉认知”障碍与阿尔茨海默病和血管性痴呆患者的岛叶受累有关：“痴呆症患者对食物的记忆受损，导致饮食不良”。
DOI：
10.1017/s1041610214000532
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Tashiro M.
中科院分区：
文献类型：
--
作者：
Suto T;Meguro K;Nakatsuka M;Kato Y;Tezuka K;Yamaguchi S;Tashiro M.
背景在痴呆症患者中，尽管没有吞咽问题，但仍可能发生饮食摄入问题。我们调查了阿尔茨海默病（AD）和血管性痴呆（VaD）patients.MethodsParticipants包括15名健康对照（HC），30 AD和20 VaD患者的食物和味觉的认知功能。食物认知测试：研究人员向每位参与者展示了三种日本流行的无气味食物的复制品，并要求他们说出每种食物的名称。随后提出了食物材料的复制品，以询问它们是否包括在这些食物中。味觉认知测试：复制品的12种食物，以描述他们的预期taste.ResultsThe AD/VaD组表现出显着较低的分数食物/味觉认知测试相比，HC组。这些分数与AD组的简易精神状态检查（MMSE）分数呈负相关。在50名患者中有12名观察到饮食摄入量减少; 12名患者中有8名表现出味觉认知测试评分降低，高于正常摄入患者。HC/AD/VaD组之间的滤纸味盘试验无差异。为了检验这一假设，即大脑皮层与味觉认知相关，两个MMSE匹配的AD亚组（n = 10 vs. 10）进行了正电子发射断层扫描。在低味觉认知亚组中，右丘脑的葡萄糖代谢较低。患有岛叶病变的VaD患者表现出味觉认知测试结果受损。结论当我们照顾痴呆症患者时，考虑饮食摄入的认知方面很重要。
BackgroundIn dementia patients, dietary intake problems may occur despite the absence of swallowing problems. We investigated cognitive functions on food and taste in Alzheimer's disease (AD) and vascular dementia (VaD) patients.MethodsParticipants included 15 healthy controls (HC), 30 AD and 20 VaD patients. Food Cognition Test: Replicas of three popular foods in Japan with no odors were presented visually to each participant, with the instruction to respond with the name of each food. Replicas of food materials were subsequently presented to ask whether they were included in these foods. Taste Cognition Test: Replicas of 12 kinds of foods were presented to describe their expected tastes.ResultsThe AD/VaD groups exhibited significantly lower scores on Food/Taste Cognition Tests compared with the HC group. These scores correlated inversely with Mini-Mental State Examination (MMSE) scores in the AD group. Decreased dietary intake was observed in 12 of the 50 patients; 8 of the 12 exhibited decreased Taste Cognition Test scores, higher than that of the normal-intake patients. There was no difference in the filter paper taste disc test between HC/AD/VaD groups. To test the hypothesis that the insula is associated with taste cognition, two MMSE-matched AD subgroups (n = 10 vs. 10) underwent positron emission tomography. Glucose metabolism in the right insula was lower in the low taste cognition subgroup. The VaD patients with insular lesions exhibited impaired Taste Cognition Test findings.ConclusionsIt is important to consider the cognitive aspect of dietary intake when we care for dementia patients.