Multi-dimensional population balance model development and validation for a twin screw granulation process
Multi-dimensional population balance model development and validation for a twin screw granulation process
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DOI：
10.1016/j.powtec.2014.06.035
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发表时间：
2015-01-01
影响因子：
5.2
通讯作者：
Ramachandran, Rohit
中科院分区：
文献类型：
--
作者：
Barrasso, Dana;El Hagrasy, Arwa;Ramachandran, Rohit
在这项研究中，建立了一种新的双螺杆造粒（TSG）过程的多组分种群平衡模型（PBM），考虑了聚集、破碎、液体添加和固结的速率过程。多种固体成分（如活性药物成分和赋形剂）与液体量之间的相互作用在量化聚集率和破损率时被考虑在内。获得了TSG工艺的实验数据，研究了初始粒径分布和液固比对颗粒关键性能的影响。这些数据用于估计所提出的机制核中的可调参数，并验证校准过程模型作为预测工具的有效性。仿真结果与实验数据吻合较好。(C) 2014 Elsevier B.V.版权所有
In this study, a novel multi-component population balance model (PBM) for the twin-screw granulation (TSG) process was developed, taking into account the rate processes of aggregation, breakage, liquid addition, and consolidation. Interactions between multiple solid components (e.g. active pharmaceutical ingredient and excipient) and the amount of liquid were accounted for in quantifying the aggregation and breakage rates. Experimental data was obtained for the TSG process, whereby the effect of initial particle size distribution and liquid-to-solid ratios on key granule properties was studied. The data was used to estimate adjustable parameters in the proposed mechanistic kernels and to validate the calibrated process model as a predictive tool. The simulation results showed a good agreement with experimental data. (C) 2014 Elsevier B.V. All rights reserved.