Investigation of the effects of acrylamide applied during pregnancy on fetal brain development in rats and protective role of the vitamin E
Investigation of the effects of acrylamide applied during pregnancy on fetal brain development in rats and protective role of the vitamin E
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DOI：
10.1177/0960327116632049
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发表时间：
2016-12-01
影响因子：
2.8
通讯作者：
Dogan, Z.
中科院分区：
文献类型：
--
作者：
Erdemli, M. E.;Turkoz, Y.;Dogan, Z.
在高温下油炸或烘焙食物会产生大量的丙烯酰胺(AA)，个人每天通过食用这些食物来摄取一定量的AA。孕妇在怀孕期间也暴露于源于食物的再生障碍性贫血，她们的胎儿可能会受到影响。将大鼠分为5组：对照组(C)、玉米油(CO)、维生素E(Vit E)、维生素A和维生素E+AA组，每组8只。妊娠第20天取胎儿，取其脑组织进行生化和组织学检查。AA导致胎儿脑组织神经元结构退化并造成出血性损害；显著降低脑源性神经营养因子水平；增加丙二醛和总抗氧化能力水平；并降低降低的谷胱甘肽和总抗氧化能力水平(p<；0.05)。另一方面，测定了神经保护剂和强力抗氧化剂维生素E在上述指标上抑制AA对胎儿发育和胎儿脑组织损伤的影响(p<；0.05)。建议食用含有维生素E的食物作为一种保护措施，以最大限度地减少食品型AA对胎儿发育的毒性影响，因为当今生活中快餐文化的广泛性质以及无法保护胎儿免受AA毒性的影响。
A liberal amount of acrylamide (AA) is produced as a result of frying or baking foods in high temperatures, and individuals take certain amounts of AA everyday by consuming these food items. Pregnant women are also exposed to AA originating from food during pregnancy and their fetus are probably affected. The rats were divided into five different groups: control (C), corn oil (CO), vitamin E (Vit E), AA, and Vit E + AA, with eight pregnant rats in each group. On the 20th day of pregnancy, fetuses were removed and brain tissues of fetuses were examined for biochemical and histological changes. AA caused degeneration in neuron structures in fetal brain tissue and caused hemorrhagic damages; dramatically decreased brain-derived neurotrophic factor levels; increased malondialdehyde, total oxidant capacity levels; and decreased reduced glutathione and total antioxidant capacity levels (p < 0.05). On the other hand, it was determined that the Vit E, a neuroprotectant and a powerful antioxidant, suppressed the effects of AA on fetal development and fetal brain tissue damage for the above-mentioned parameters (p < 0.05). It is recommended to consume food containing Vit E as a protection to minimize the toxic effects of food-oriented AA on fetus development due to the widespread nature of fast-food culture in today's life and the impossibility of protection from AA toxicity.