PROPHYLACTIC PUVA AND UVB THERAPY IN POLYMORPHIC LIGHT ERUPTION - A CONTROLLED TRIAL
PROPHYLACTIC PUVA AND UVB THERAPY IN POLYMORPHIC LIGHT ERUPTION - A CONTROLLED TRIAL
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DOI：
10.1111/j.1365-2133.1987.tb05874.x
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发表时间：
1987-04-01
影响因子：
10.3
通讯作者：
MAGNUS, IA
中科院分区：
文献类型：
--
作者：
MURPHY, GM;LOGAN, RA;MAGNUS, IA
1983年4月至9月对42例多形性日光疹（PLE）患者进行了小剂量预防性口服光化学疗法（PUVA）和紫外线B（UVB）照射治疗的双盲对照试验。患者被随机分配到三组，PUVA与口服8-甲氧基补骨脂素（8-MOP），UVB与口服安慰剂，和对照低剂量UVA与口服安慰剂。给予每个活性治疗组的初始剂量为预定最小光毒性或红斑剂量的三分之一，随后每周三次，持续6周，PUVA组每次增加八分之一的剂量，UVB组增加七分之一的剂量。紫外线辐射暴露监测与聚砜薄膜翻领徽章。患者在视觉模拟量表上记录他们的症状。与对照组相比，接受PUVA和UVB治疗的患者的皮疹和瘙痒症状受紫外线辐射暴露增加的影响明显较小。
A double-blind controlled trial of low-dose prophylactic oral psoralen photochemotherapy (PUVA) and ultraviolet-B (UVB) irradiation therapy was undertaken from April to September 1983 in 42 patients with polymorphic light eruption (PLE). Patients were randomly allocated to three groups, PUVA with oral 8-methoxypsoralen (8-MOP), UVB with oral placebo, and control low-dose UVA with oral placebo. The initial dose given to each active treatment group was a third of the predetermined minimal phototoxic or erythema dose, followed three times weekly for 6 weeks by doses incremented by an eighth on each occasion in the PUVA group and by a seventh in the UVB group. Ultraviolet radiation exposure was monitored throughout with polysulphone film lapel badges. Patients recorded their symptoms on a visual analogue scale. Symptoms of rash and itch in patients treated with PUVA and UVB were significantly less affected by increasing exposure to ultraviolet radiation than were these symptoms in control patients.