Prevention of Periinfarct Direct Current Shifts with Glutamate Antagonist NBQX following Occlusion of the Middle Cerebral Artery in the Rat
Prevention of Periinfarct Direct Current Shifts with Glutamate Antagonist NBQX following Occlusion of the Middle Cerebral Artery in the Rat
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谷氨酸拮抗剂 NBQX 预防大鼠大脑中动脉闭塞后梗塞周围直流电转移
DOI：
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发表时间：
1994
影响因子：
6.3
通讯作者：
K. Hossmann
中科院分区：
文献类型：
--
作者：
G. Mies;K. Kohno;K. Hossmann
谷氨酸（AMPA亚型）受体拮抗剂NBQX对梗死周围直流（DC）的变化和皮质ATP耗竭量的影响进行了检查大鼠大脑中动脉（MCA）闭塞3小时。大脑中动脉闭塞产生了立即DC移位周围的缺血领土。溶剂处理（未处理）动物在3小时闭塞时间内出现1 - 5次额外的DC偏移（中位数，2）。NBQX治疗（2 × 30 mg/kg，MCA闭塞后立即静脉注射，1小时后）显著减少了DC偏转的数量（中位数，0;范围，0-2; p < 0.05），而不改变梗死边缘区的血流（未治疗，50.6 ± 10.6%; NBQX治疗：对照组的51.9 ± 7.7%;平均值± SD）。NBQX治疗显著降低了ATP消耗的皮质体积（未治疗，75.3 ± 11.4 mm 3; NBQX治疗，47.9 ± 10.1 mm 3; p < 0.05）。梗死灶周围DC移位数与脑皮质ATP耗竭量呈显著线性关系（y = 38.3 + 9.4x; r = 0.866; p < 0.001）。NBQX治疗脑梗死体积的减少是通过抑制DC移位和降低血流动力学受损皮质中的代谢工作负荷来解释的。
The effect of the glutamate (AMPA subtype) receptor antagonist NBQX on periinfarct direct current (DC) shifts and cortical ATP depletion volume was examined in rats subjected to 3 h of occlusion of the middle cerebral artery (MCA). MCA occlusion produced an immediate DC shift in the periphery of the ischemic territory. Vehicle-treated (untreated) animals developed one to five additional DC shifts (median, 2) during the 3-h occlusion time. NBQX treatment (2 × 30 mg/kg i.v. immediately after MCA occlusion and 1 h later) significantly reduced the number of DC deflections (median, 0; range, 0–2; p < 0.05) without changing blood flow in the border zone of the infarct (untreated, 50.6 ± 10.6%; NBQX-treated: 51.9 ± 7.7% of control; mean ± SD). NBQX treatment significantly decreased the cortical volume of ATP depletion (untreated, 75.3 ± 11.4 mm3; NBQX-treated, 47.9 ± 10.1 mm3; p < 0.05). Moreover, a significant linear relationship between the number of periinfarct DC shifts and the volume of cortical ATP depletion was obtained (y = 38.3 + 9.4x; r = 0.866; p < 0.001). The reduction of brain infarct volume by NBQX treatment is explained by the suppression of DC shifts and the decrease of metabolic workload in hemodynamically compromised cortex.
DOI：
10.1073/pnas.87.16.6445
发表时间：
1990-08-01
影响因子：
11.1
作者：
TANG, CM;DICHTER, M;MORAD, M
通讯作者：
MORAD, M