Tickborne infections as a cause of nonspecific febrile illness in Wisconsin
Tickborne infections as a cause of nonspecific febrile illness in Wisconsin
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DOI：
10.1086/320160
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发表时间：
2001-05-15
影响因子：
11.8
通讯作者：
Kazmierczak, JJ
中科院分区：
文献类型：
--
作者：
Belongia, EA;Reed, KD;Kazmierczak, JJ
莱姆病、人粒细胞埃立克体病（HGE）和巴贝西虫病是威斯康星州特有的蜱传感染。为了评估它们作为非特异性发热原因的重要性，我们从1997年5月至1998年8月在威斯康星州西北部的10个诊所招募了发热性疾病患者。符合条件的患者体温>38.0 ℃，但没有皮疹或其他局部来源。急性和恢复期的血清学试验进行伯氏疏螺旋体，巴贝氏田鼠，和马埃立克体;聚合酶链反应进行检测粒细胞埃立克体rDNA。62例合格患者中有17例（27%）有蜱传感染的实验室证据，包括7例（11%）仅可能患有莱姆病，8例（13%）仅患有HGE，2例（3%）明显合并感染。未发现巴氏杆菌感染患者。有和没有蜱传感染的患者在年龄、性别、症状、蜱叮咬史和户外暴露方面相似。结果表明，蜱传感染是威斯康星州西北部蜱虫季节非特异性发热性疾病的一个重要原因。
Lyme disease, human granulocytic ehrlichiosis (HGE), and babesiosis are tickborne infections that are indigenous to Wisconsin. To assess their importance as a cause of nonspecific fever, we recruited patients with febrile illness at 10 clinics in northwestern Wisconsin from May through August of both 1997 and 1998. Eligible patients had a temperature >38.0 degreesC but no rash or other localizing source. Acute and convalescent serological tests were performed for Borrelia burgdorferi, Babesia microti, and Ehrlichia equi; polymerase chain reaction was performed to detect granulocytic Ehrlichia rDNA. Seventeen (27%) of 62 eligible patients had laboratory evidence of tickborne infection, including 7 (11%) with probable Lyme disease only, 8 (13%) with HGE only, and 2 (3%) with apparent coinfection. No patients with Babesia infection were identified. Patients with and without tickborne infection were similar with regard to age, sex, symptoms, history of tick bite, and outdoor exposure. The results suggest that tickborne infections are an important cause of nonspecific febrile illness during the tick season in northwestern Wisconsin.