Functional optical hemodynamic imaging of the olfactory cortex
Functional optical hemodynamic imaging of the olfactory cortex
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DOI：
10.1097/mlg.0b013e31802ffe2a
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发表时间：
2007-03-01
期刊：
影响因子：
2.6
通讯作者：
Mori, Nozomu
中科院分区：
文献类型：
--
作者：
Kobayashi, Eiji;Kusaka, Takashi;Mori, Nozomu
目的：我们使用多通道近红外光谱（MNIRS）来监测额叶皮层的活动，如嗅觉刺激下的血流动力学反应所反映的那样。本研究的目的是阐明嗅觉活动的功能性脑成像。研究设计：前瞻性研究。方法：本研究针对 8 名年龄在 22 至 39 岁之间的健康受试者（4 名男性和 4 名女性；平均年龄为 28.8 岁）进行。我们使用了 22 通道近红外光谱装置，具有 8 个光入射光纤和 7 个检测器光纤，每个光纤在额叶区域的光极间距离为 2.5 cm。嗅觉刺激包括五次重复，每次持续 5 秒，然后是 55 秒的休息时间。使用异戊酸作为气味刺激，并使用盐水作为对照。我们测量了氧合血红蛋白 [oxyHb]、脱氧血红蛋白 [deoxyHb] 和总血红蛋白 [totalHb] 浓度相对于基线值的变化。此外，我们将额叶皮层分为四个区域（右上、左上、右下、左下）并研究每个区域的活动。结果：异戊酸引起变化，特别是在下部区域，但盐水没有引起变化。气味刺激后[氧血红蛋白]和[总血红蛋白]增加，但[脱氧血红蛋白]没有变化。这些活跃区域可能与眶额皮质有关，对应于嗅觉皮质。结论：本研究表明，MNIRS 能够通过嗅觉刺激评估与大脑活动相关的血流动力学变化。
Objective: We used multichannel near-infrared spectroscopy (MNIRS) to monitor the activity of the frontal cortex as mirrored by hemodynamic responses subjected to olfactory stimulation. The aim of this study was to clarify the functional brain imaging of olfactory activity. Study Design: Prospective study. Methods: This study was conducted on eight healthy subjects aged from 22 to 39 years (4 men and 4 women; mean age, 28.8 yr). We used a 22-channel near-infrared spectroscopy device with eight light-incident fibers and seven detector fibers, each with an interoptode distance of 2.5 cm on the frontal region. Olfactory stimulation consisted of five repetitions, each lasting 5 seconds and followed by a 55 seconds rest period. Isovaleric acid was used as odor stimulation, and saline was used as a control. We measured the changes in concentrations of oxyhemoglobin [oxyHb], deoxyhemoglobin [deoxyHb], and total hemoglobin [totalHb] from prebaseline values. Furthermore, we divided the frontal cortex into four areas (right upper, left upper, right lower, left lower) and investigated the activity in each area. Results: Isovaleric acid caused changes, especially in the lower area, but saline caused no changes. [oxyHb] and [totalHb] increased after odor stimulation, but [deoxyHb] did not change. These active areas may be related to the orbitofrontal cortex, corresponding to olfactory cortices. Conclusion: This study has shown that MNIRS enables evaluation of changes in hemodynamics related to brain activity by olfactory stimulation.