Lack of causal relationship between leukocyte telomere length and coronary heart disease
Lack of causal relationship between leukocyte telomere length and coronary heart disease
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DOI：
10.1016/j.atherosclerosis.2014.01.008
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发表时间：
2014-04-01
期刊：
影响因子：
5.3
通讯作者：
Wang, Dao Wen
中科院分区：
文献类型：
--
作者：
Cui, Guanglin;Sun, Jing;Wang, Dao Wen
目的：目的探讨端粒酶RNA组分（TERC）和白细胞端粒长度（LTL）基因变异与冠心病（CHD）的关系。此外，LTL比率在病例对照设置中确定，涉及4351名参与者：2211名健康个体和2140名CHD患者。检测LTL与心脑血管病变的存在和程度之间的关系。结果证实了rs 12696304和rs 16847897与中国汉族人群中的LTL相关（P = 1.63 x 10（-6）和P = 1.44 x 10（-7））。然而，这些SNP赋予CHD中度风险，但在多次校正后未达到显著阈值。LTL比值降低与CHD相关（比值比[OR]，1.13; 95%可信区间[CI]，1.02-1.34; P < 0.01）。此外，冠心病患者的LTL比率与血管病变的数量有关。结论：我们的研究结果不支持LTL对冠心病发展的因果作用。然而，LTL可能与复杂的条件相关的心脑血管疾病的表现。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Objective: To investigate the association between genetic variation in telomerase RNA component (TERC) and leukocyte telomere length (LTL) with risk of coronary heart disease (CHD).Methods and results: An analysis of LTL was conducted, focusing on two SNPs in 2 community-based cohort populations comprising 3500 Chinese Han individuals. In addition, LTL ratio was determined in a case-control setting involving 4351 participants: 2211 healthy individuals and 2140 CHD patients. The association between LTL and the presence and extent of cardiovascular and cerebrovascular lesions were tested. Results confirmed the association of rs12696304 and rs16847897 with LTL in the Chinese Han population (P = 1.63 x 10(-6) and P = 1.44 x 10(-7), respectively). However, these SNPs confer a moderate risk for CHD but did not achieve significant threshold after multiple corrections. Decreased LTL ratio was associated with CHD (odds ratio [OR], 1.13; 95% confidence interval [CI], 1.02-1.34; P < 0.01). In addition, the LTL ratio in CHD patients was related to numbers of vascular disease lesions.Conclusions: Our results do not support a causal role of LTL for the development of CHD. However, LTL may be related to complex conditions associated with cardiovascular and cerebrovascular disease manifestations. (C) 2014 Elsevier Ireland Ltd. All rights reserved.