Involvement of Microglia in the Pathophysiology of Intracranial Aneurysms and Vascular Malformations-A Short Overview.
Involvement of Microglia in the Pathophysiology of Intracranial Aneurysms and Vascular Malformations-A Short Overview.
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DOI：
10.3390/ijms22116141
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发表时间：
2021-06-07
影响因子：
5.6
通讯作者：
Florian IS
中科院分区：
文献类型：
--
作者：
Timis TL;Florian IA;Susman S;Florian IS
脑动脉瘤和血管畸形是颅内出血和随后的死亡率和发病率的重要来源。我们才刚刚开始认识到中枢神经系统的常驻免疫细胞小胶质细胞在这些疾病及其结果中的作用。最近的证据表明，激活的促炎小胶质细胞与蛛网膜下腔出血（SAH）急性期和慢性期脑损伤的扩张有关，也是血管痉挛的主要因素，而血管痉挛是SAH最严重的并发症。另一方面，抗炎小胶质细胞可能参与脑损伤和出血的消退。这些免疫细胞也在脑动静脉畸形（bAVM）和脑海绵状瘤（CCM）中大量存在，尽管它们在这些病变中的作用目前还不完全确定。下面的综述旨在阐明与小胶质细胞及其在颅内动脉瘤和血管畸形中的作用相关的最重要的发现，并可能为未来的研究奠定基础。
Aneurysms and vascular malformations of the brain represent an important source of intracranial hemorrhage and subsequent mortality and morbidity. We are only beginning to discern the involvement of microglia, the resident immune cell of the central nervous system, in these pathologies and their outcomes. Recent evidence suggests that activated proinflammatory microglia are implicated in the expansion of brain injury following subarachnoid hemorrhage (SAH) in both the acute and chronic phases, being also a main actor in vasospasm, considerably the most severe complication of SAH. On the other hand, anti-inflammatory microglia may be involved in the resolution of cerebral injury and hemorrhage. These immune cells have also been observed in high numbers in brain arteriovenous malformations (bAVM) and cerebral cavernomas (CCM), although their roles in these lesions are currently incompletely ascertained. The following review aims to shed a light on the most significant findings related to microglia and their roles in intracranial aneurysms and vascular malformations, as well as possibly establish the course for future research.
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影响因子：
2.4
作者：
Chang, Chih-Zen;Wu, Shu-Chuan;Hwang, Shiuh-Lin
通讯作者：
Hwang, Shiuh-Lin
影响因子：
5.3
作者：
Duan, Hongzhou;Li, Liang;Zhang, Jiayong
通讯作者：
Zhang, Jiayong
影响因子：
4.1
作者：
Ferrier, Cyrille H.;Aronica, Eleonora;Van Huffelen, Alexander C.
通讯作者：
Van Huffelen, Alexander C.
DOI：
10.1212/con.0000000000000418
发表时间：
2017-02-01
期刊：
Continuum (Minneapolis, Minn.)
影响因子：
--
作者：
Flemming, Kelly D;Lanzino, Giuseppe
通讯作者：
Lanzino, Giuseppe
影响因子：
16.2
作者：
Abud EM;Ramirez RN;Martinez ES;Healy LM;Nguyen CHH;Newman SA;Yeromin AV;Scarfone VM;Marsh SE;Fimbres C;Caraway CA;Fote GM;Madany AM;Agrawal A;Kayed R;Gylys KH;Cahalan MD;Cummings BJ;Antel JP;Mortazavi A;Carson MJ;Poon WW;Blurton-Jones M
通讯作者：
Blurton-Jones M