Expression of hepatocyte carbonic anhydrase isoenzymes in vitro and in vivo
Expression of hepatocyte carbonic anhydrase isoenzymes in vitro and in vivo
复制标题
肝细胞碳酸酐酶同工酶的体内外表达
DOI：
10.1042/bst0150667
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发表时间：
1987
影响因子：
3.9
通讯作者：
G. Lönnerholm
中科院分区：
文献类型：
--
作者：
N. Carter;S. Jeffery;R. Legg;P. Wistrand;G. Lönnerholm
大鼠肝脏含有高活性和低活性的碳酸酐酶（CA），最近被鉴定为同工酶CAI 1和CAIII，使用特定的放射免疫测定。这些同工酶在大鼠肝脏中表现出生长激素介导的性二态性，与雌性相比，雄性大鼠肝脏中的CAIII浓度高出30倍，而雌性肝脏中的CAI 1浓度高出3-4倍。（1986年）。也有证据表明，肝脏中存在一种特异性α 1型碳酸酐酶，其在尿素生产中发挥作用。（1980年）。
Rat liver contains both high-and low-activity cytoplasmic forms of carbonic anhydrase (CA), identified recently as the isoenzymes CAI1 and CAIII, using specific radioimmunoassay. These isoenzymes exhibit growth hormone-mediated sexual dimorphism in rat liver with CAIII present at up to 30 times greater concentration in the male rat liver, compared with the female, in contrast with CAI1 which is 3-4 times higher in the female liver Jeffery et al.(1986). There is also evidence for a specific mitochondria1 form of carbonic anhydrase in liver which functions in the production of urea Dodgson et al.(1 980).