Acute Effects of Intranasal Oxytocin on Subjective and Behavioral Responses to Social Rejection
Acute Effects of Intranasal Oxytocin on Subjective and Behavioral Responses to Social Rejection
复制标题
DOI：
10.1037/a0019719
复制
发表时间：
2010-08-01
影响因子：
2.3
通讯作者：
Guastella, Adam J.
中科院分区：
文献类型：
--
作者：
Alvares, Gail A.;Hickie, Ian B.;Guastella, Adam J.
这种荷尔蒙和神经肽催产素被认为可以缓冲社交压力，减少社交威胁的感觉。我们采用了一种广泛使用的排斥范式，Cyberball，来研究催产素是否改善了社会排斥的急性行为和情感后果。在双盲、随机、受试者之间的设计中，74名健康的男性和女性参与者被鼻内注射催产素或安慰剂，随后在这场虚拟投球游戏中被排斥或被包括在内。被排斥的参与者报告了负面的情感和依恋相关的反应，以及参与游戏意愿增加的显著动机变化；这些影响不受催产素的影响。然而，鼻腔内催产素的增加确实包括了参与者再次与相同参与者玩耍的愿望，这表明在被纳入后，催产素增强了对未来社会参与的渴望。这些发现被认为是为了提供证据，证明催产素在促进社交接近行为中的作用可能是特定于背景的，并且对积极的社交线索敏感。结果表明，在一个明显厌恶的背景下，催产素并不能缓冲迟钝的社会排斥的直接影响。
The hormone and neuropeptide oxytocin is believed to buffer against social stress and reduce social-threat perception. We employed a widely used ostracism paradigm, Cyberball, to investigate whether oxytocin ameliorated the acute behavioral and affective consequences of social rejection. In a double-blind, randomized, between-subjects design, 74 healthy male and female participants were administered intranasal oxytocin or placebo and subsequently ostracized or included during this virtual ball-tossing game. Ostracized participants reported negative affective and attachment-related reactions, as well as a significant motivational change in increased desire to be involved in the game; these effects were not influenced by oxytocin. Intranasal oxytocin did, however, increase included participants' desire to play again with the same participants, suggesting oxytocin enhanced desire for future social engagement following inclusion. These findings are argued to provide evidence that the effects of oxytocin in promoting social approach behavior may be context specific and sensitive to positive social cues. The results suggest that in an explicitly aversive context, oxytocin does not buffer against the immediate impact of blunt social rejection.