Stress response patterns of plasma corticosterone, prolactin, and growth hormone in the rat, following handling or exposure to novel environment.
Stress response patterns of plasma corticosterone, prolactin, and growth hormone in the rat, following handling or exposure to novel environment.
复制标题
处理或暴露于新环境后，大鼠血浆皮质酮、催乳素和生长激素的应激反应模式。
DOI：
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发表时间：
1975
影响因子：
2.1
通讯作者：
G. Brown
中科院分区：
文献类型：
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作者：
J. Seggie;G. Brown
比较了刺激后0、5、15、30和60min大鼠肾上腺昼夜节律峰谷时皮质酮、催乳素和生长激素对5-S和3分钟新环境的反应。所有激素对刺激都有反应，皮质酮和催乳素急剧上升，生长激素急剧下降。静息皮质酮水平证明了预期的日变化，在研究的时间段，催乳素而不是生长激素也显示出小幅度的基线日变化。生长激素反应特性不受一天中的时间或刺激类型的影响。皮质酮和催乳素的反应曲线在一天中的两个时间段和在两种类型的刺激之后都不同。皮质酮和催乳素水平高度相关，与生长激素水平呈负相关。这项研究证实，荷尔蒙对压力的反应是复杂的，不仅取决于刺激，还取决于刺激的背景。
Corticosterone, prolactin, and growth hormone responses to 5 s of handling or 3 min of novel environment were compared in rats at crest and trough of the diurnal adrenal rhythm 0, 5, 15, 30, and 60 min after stimulation. All hormones responded to stimulation, corticosterone and prolactin with a dramatic rise, and growth hormone with a precipitous fall. Resting corticosterone levels evidenced the expected diurnal variation, and prolactin but not growth hormone also showed a baseline diurnal variation of small magnitude at the times studied. Growth hormone response characteristics were unaffected by time of day or type of stimulation. Both corticosterone and prolactin response profiles differed at both times of day and following both types of stimulation. Corticosterone and prolactin levels were highly correlated and each was negatively correlated with growth hormone levels. This study confirms that hormone responses to stress are complex and depend not only on the stimulus but the context of stimulation.