Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages
Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages
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DOI：
10.1128/aac.48.6.2325-2330.2004
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发表时间：
2004-06-01
影响因子：
4.9
通讯作者：
Gage, PW
中科院分区：
文献类型：
--
作者：
Ewart, GD;Nasr, N;Gage, PW
我们报告了阿米洛利类似物5-（N，N '-二甲基）阿米洛利和5-（N，N'-二甲基）阿米洛利在微摩尔浓度下抑制人免疫缺陷病毒1型（HIV-1）在培养的人血单核细胞衍生的巨噬细胞中的复制。这些化合物还抑制HIV-1 Vpu蛋白的体外活性，并可能代表一类新的抗HIV-1药物的先导化合物。
We report that the amiloride analogues 5-(N,N'-hexamethylene)amiloride and 5-(N,N'-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.