Attention-related modifications of ultra-late CO2 laser evoked potentials to human trigeminal nerve stimulation
Attention-related modifications of ultra-late CO2 laser evoked potentials to human trigeminal nerve stimulation
复制标题
超晚CO2激光诱发电位对人三叉神经刺激的注意相关修饰
DOI：
10.1016/s0304-3940(02)00671-7
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发表时间：
2002
影响因子：
2.5
通讯作者：
P. Tonali
中科院分区：
文献类型：
--
作者：
Massimiliano Valeriani;D. Restuccia;D. Pera;L. Armas;P. Tonali
我们的研究旨在研究与 C 纤维激活相关的超晚期 CO2 激光诱发电位 (LEP) 的头皮地形，并探讨注意偏差对超晚期 LEP 的影响。记录了 10 名健康受试者在三种不同条件下对无痛 CO2 激光刺激的大脑反应：(i) 中性条件，受试者没有任何任务； (ii) 受试者被要求执行数学任务的分心状态； (iii) 受试者必须计算刺激数量的注意力状态。在所有受试者中，在痛苦的 CO2 激光刺激后也记录了 Að 纤维相关的晚期 LEP。注意力状态下的超晚 LEP 包括对侧颞区较早的负电位（超晚 N1）和同时额叶的正反应（超晚 P1）。后来，可识别出顶点双相成分（超晚期 N2a 和超晚期 P2）。在中性和分散状态下，顶点超晚 LEP 幅度均显着降低。超晚期LEP的潜伏期比晚期LEP更长，但超晚期和晚期LEP的头皮分布非常相似，因此表明它们的产生可能涉及相同的大脑区域。由于注意力偏差对超晚期 LEP 幅度有很大影响，因此当超晚期 LEP 用于临床目的时，受试者的注意力应集中在 CO2 激光刺激上。
Our study aimed at investigating the scalp topography of ultra-late CO2laser evoked potentials (LEPs), which are related to C fiber activation, and at exploring the effect of attention deviation on ultra-late LEPs. Brain responses to non-painful CO2laser stimuli were recorded in ten healthy subjects in three different conditions: (i) neutral condition in which subjects did not have any task; (ii) distraction condition in which subjects were asked to perform a mathematical task; and (iii) attention condition in which subjects had to count the number of stimuli. In all subjects, also Að fiber-related late LEPs were recorded after painful CO2laser stimulation. The ultra-late LEPs in attention condition included an earlier negative potential (ultra-late N1) in the contralateral temporal region and a simultaneous frontal positive response (ultra-late P1). Later, a vertex biphasic component (ultra-late N2a and ultra-late P2) was identifiable. The vertex ultra-late LEP amplitude was significantly decreased in both neutral and distraction condition. Ultra-late LEPs showed a longer latency than late LEPs, but the scalp distributions of both ultra-late and late LEPs were very similar, thus suggesting that the same cerebral areas may be involved in their generation. Since attention deviations have a strong effect on ultra-late LEP amplitude, the subject's attention should be addressed to CO2laser stimuli when ultra-late LEPs are used for clinical purposes.