ULTRASTRUCTURE OF ANOTHER SPIRAL ORGANISM ASSOCIATED WITH HUMAN GASTRITIS
ULTRASTRUCTURE OF ANOTHER SPIRAL ORGANISM ASSOCIATED WITH HUMAN GASTRITIS
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DOI：
10.1007/bf01540059
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发表时间：
1989-11-01
影响因子：
3.1
通讯作者：
MCCALLUM, RW
中科院分区：
文献类型：
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作者：
DYE, KR;MARSHALL, BJ;MCCALLUM, RW
幽门弯曲菌可能不是引起人类活动性慢性胃炎的唯一病原体。我们报告两例胃感染的螺旋菌，与幽门弯曲菌不同。幽门。第一位患者是一位36岁的女性，从童年开始就表现出上腹痛和腹绞痛，她养了14只猫。内窥镜检查正常。第二个病人养了两只狗。两例患者的胃粘膜活检标本的组织学显示活动性慢性胃炎，在身体粘膜中最严重。Giemsa染色显示细菌有4 ~ 8个螺旋，直径0.5 μm，长度3-7 μm。该生物体在极部有多个鞘状鞭毛，细胞壁光滑，无轴丝。这些生物体类似于在猫、狗和非人类灵长类动物中观察到的胃囊。经次水杨酸铋、阿莫西林和甲硝唑抗菌治疗后，两例患者的微生物消失，胃炎愈合。pylori感染时，这种新的幽门螺杆菌更喜欢定植在含有壁细胞的胃粘膜上。虽然这种类型的生物体是其他哺乳动物中常见的寄生虫，但它似乎与人类胃炎有关，并且可能是人类胃炎的原因。
Campylobacter pylorimay not be the only organism that causes active chronic gastritis in man. We report two cases of gastric infection with a spiral organism distinct fromC. pylori. The first patient is a 36-year-old female who presented with epigastric pain and abdominal colic present since childhood and who had 14 cats. Endoscopy was normal. The second patient kept two dogs. Histology of gastric mucosal biopsy specimens in both patients revealed active chronic gastritis, most severe in body mucosa. Giemsa stain revealed bacteria with four to eight spirals, 0.5 μm in diameter and 3–7 μm in length. The organisms had multiple sheathed flagella at the pole and smooth cell walls without axial filaments. The organisms resembled the gastric spirillum that has been seen in cats, dogs, and nonhuman primates. After antibacterial therapy with bismuth subsalicylate, amoxicillin, and metronidazole, the organisms disappeared in both patients and the gastritis healed.UnlikeC. pylori, this new spirillum prefers to colonize gastric mucosa containing parietal cells. Whereas this type of organism is a common commensal in other mammals, it appears to be associated with and a possible cause of gastritis in humans.