Bottom-up synthesis of WS2 nanosheets with synchronous surface modification for imaging guided tumor regression
Bottom-up synthesis of WS2 nanosheets with synchronous surface modification for imaging guided tumor regression
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自下而上合成具有同步表面修饰的 WS2 纳米片，用于成像引导肿瘤消退
DOI：
10.1016/j.actbio.2017.06.014
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发表时间：
2017-08-01
影响因子：
9.7
通讯作者：
Huang, Mingxian
中科院分区：
文献类型：
--
作者：
Wang, Shige;Zhao, Jiulong;Huang, Mingxian
二维过渡金属二硫化物（TMDs）作为近红外光热传导剂在肿瘤光热治疗中受到广泛关注。考虑到传统自上而下剥离的二维TMD的低效率及其表面修饰的复杂性，我们在此提出了一种自下而上的策略，用于表面聚乙烯吡咯烷酮（PVP）修饰的WS2纳米片的一锅水热和受控合成。该材料设计基于PVP羰基氧的孤对电子与钨的未占据轨道（5d轨道）之间的螯合配位效应。表面同步接枝PVP的WS2纳米片表现出优异的光热转换性能，而表面锚定的PVP保证了其胶体稳定性。此外，WS2-PVP360kDa强大的X射线衰减能力和近红外（NIR）吸光度使得敏感的体外和体内计算机断层扫描和光声成像成为可能。 WS2-PVP360kDa 纳米片具有生物相容性，并在体外和体内表现出良好的抗癌功效。本报告的研究结果可能会极大地促进胶体稳定和生物相容性二维TMD的设计及其未来的临床转化。意义声明首次提出了表面聚乙烯吡咯烷酮（PVP）修饰的WS2纳米片的一锅法和受控合成的自下而上策略。通过对四硫钨酸盐和PVP的混合溶液进行水热处理，利用PVP羰基氧的孤对电子与钨的空位轨道（5d轨道）之间的螯合配位作用，将PVP同步绘制在WS2-PVP纳米片表面。形成的WS2-PVP纳米片胶体稳定、生物相容性好，在体外和体内均表现出良好的计算机断层扫描、光声成像和肿瘤光热治疗功效。 (C) 2017 Acta Materialia Inc. 由 Elsevier Ltd 出版。保留所有权利。
Two-dimensional transition metal dichalcogenides (TMDs) have been receiving great attention as NIR photothermal transducing agent in tumor photothermal therapy. Keeping in mind the low efficiency of the conventional top-down exfoliated 2D TMDs and the complexity of their surface modifications, we herein proposed a bottom-up strategy for the one-pot hydrothermal and controlled synthesis of surface polyvinyl pyrrolidone (PVP) modified WS2 nanosheets. The material design was based on the chelatingcoordinating effect between the lone pair electrons of oxygen of PVP carbonyl group and the unoccupied orbital (5d orbitals) of tungsten. The WS2 nanosheets with synchronous surface PVP grafting showed an excellent photothermal conversion performance, while the surface anchored PVP guaranteed its colloidal stability. Moreover, the strong X-ray attenuation ability and near-infrared (NIR) absorbance of WS2-PVP360kDa enabled the sensitive in vitro and in vivo computed tomography and photoacoustic imaging. The WS2-PVP360kDa nanosheets were biocompatible and exhibited promising in vitro and in vivo anticancer efficacy. Findings in this report may greatly promote the design of colloidal stable and biocompatible 2D TMDs and their future clinical translations.Statement of SignificanceA bottom-up strategy for the one-pot and controlled synthesis of surface polyvinyl pyrrolidone (PVP) modified WS2 nanosheets was proposed for the first time. By hydrothermally treating the mixture solution of tetrathiotungstate and PVP, Owing to the chelating-coordinating effect between the lone pair electrons of oxygen of PVP carbonyl group and the unoccupied orbital (5d orbitals) of tungsten, PVP was synchronously graphed on WS2-PVP nanosheets surface. The formed WS2-PVP nanosheets were colloidal stable, biocompatible, and exhibited promising computed tomography, photoacoustic imaging and tumor photothermal therapy efficacy both in vitro and in vivo. (C) 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.