Pathophysiological functions of nitric oxide-mediated protein modifications
Pathophysiological functions of nitric oxide-mediated protein modifications
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DOI：
10.1016/j.tox.2004.11.018
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发表时间：
2005-03-15
期刊：
影响因子：
4.5
通讯作者：
Gow, A
中科院分区：
文献类型：
--
作者：
Ischiropoulos, H;Gow, A
特定的翻译后修饰产生的反应一氧化氮或一氧化氮衍生的活性氮物种与选择性蛋白质可以解释这种分子在生物系统中的多效性效应。三个特定的反应，结合到金属中心，亲核中心的亚硝化和芳香族残基的硝化构成了一氧化氮的生物反应性的主要组成部分。我们假设，一氧化氮在生物系统内的化学反应性允许这种简单的双原子分子作为生理稳态的整合剂，并可能在不完全理解的情况下作为病理表型的介体。本章综述了化学，推定的生物学功能和意义的主要一氧化氮介导的蛋白质修饰。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Specific post-translational modifications resulting from the reaction of nitric oxide or nitric oxide-derived reactive nitrogen species with selective proteins may explain the pleiotropic effects of this molecule in biological systems. Three specific reactions, binding to metal centers, nitrosation of nucleophilic centers and nitration of aromatic residues constitute a major component of the biological reactivity of nitric oxide. We postulate that the chemical reactivity of nitric oxide within biological systems allows this simple diatomic molecule to operate as an integrator of physiological homeostasis and potentially under not completely understood circumstances as a mediator of pathological phenotypes. This chapter reviews the chemistry, putative biological functions and significance of the principal nitric oxide-mediated proteins modifications. (C) 2004 Elsevier Ireland Ltd. All rights reserved.