Red meat consumption and risk of stroke in Swedish men
Red meat consumption and risk of stroke in Swedish men
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DOI：
10.3945/ajcn.111.015115
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发表时间：
2011-08-01
影响因子：
7.1
通讯作者：
Wolk, Alicja
中科院分区：
文献类型：
--
作者：
Larsson, Susanna C.;Virtamo, Jarmo;Wolk, Alicja
背景：食用红肉和加工肉与几种疾病有关。然而，关于肉类消费与中风发病率的相关数据很少。目的：我们的目标是检查红肉和加工肉类的消费与男性中风发病率的关系。设计：我们前瞻性地跟踪了40,291名年龄在45-79岁之间的男性，他们在基线水平上没有心血管疾病或癌症病史。结果：在平均10.1年的随访期内，瑞典医院出院登记处共鉴定出2409例卒中事件，其中脑梗塞1849例，出血性卒中350例，不明原因卒中210例。食用加工肉类，而不是新鲜红肉，与中风风险呈正相关。加工肉类与新鲜红肉相比，总中风发生的多变量相对危险度分别为1.23(95%CI：1.0 7，1.4；P趋势=0.004)和1.0 7(95%CI：0.93，1.2 4；P趋势=0.77)。在最高和最低五分之一的比较中，加工肉类消费也与脑梗塞的风险呈正相关(RR：1.18；95%CI：1.01，1.38；趋势=0.03)。结论：男性前瞻性队列的研究结果表明，加工肉类消费与中风风险呈正相关。瑞典男性队列在Clinicaltrials.gov上注册为NCT01127711。AM J Clin Nutr 2011；94：417-21。
Background: Red and processed meat consumption has been implicated in several diseases. However, data on meat consumption in relation to stroke incidence are sparse.Objective: Our objective was to examine the associations of red meat and processed meat consumption with stroke incidence in men.Design: We prospectively followed 40,291 men aged 45-79 y who had no history of cardiovascular disease or cancer at baseline. Meat consumption was assessed with a self-administered questionnaire in 1997.Results: During a mean follow-up of 10.1 y, 2409 incident cases of stroke (1849 cerebral infarctions, 350 hemorrhagic strokes, and 210 unspecified strokes) were identified from the Swedish Hospital Discharge Registry. Consumption of processed meat, but not of fresh red meat, was positively associated with risk of stroke. The multivariable relative risks (RRs) of total stroke for the highest compared with the lowest quintiles of consumption were 1.23 (95% CI: 1.07, 1.40; P for trend = 0.004) for processed meat and 1.07 (95% CI: 0.93, 1.24; P for trend = 0.77) for fresh red meat. Processed meat consumption was also positively associated with risk of cerebral infarction in a comparison of the highest with the lowest quintile (RR: 1.18; 95% CI: 1.01, 1.38; P for trend = 0.03).Conclusion: The findings from this prospective cohort of men indicate that processed meat consumption is positively associated with risk of stroke. The Cohort of Swedish Men is registered at clinicaltrials.gov as NCT01127711. Am J Clin Nutr 2011;94:417-21.