Radiographic patterns of symptomatic radiation pneumonitis in lung cancer patients: Imaging predictors for clinical severity and outcome
Radiographic patterns of symptomatic radiation pneumonitis in lung cancer patients: Imaging predictors for clinical severity and outcome
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DOI：
10.1016/j.lungcan.2020.03.023
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发表时间：
2020-07-01
期刊：
影响因子：
5.3
通讯作者：
Nishino, Mizuki
中科院分区：
文献类型：
--
作者：
Thomas, Richard;Chen, Yu-Hui;Nishino, Mizuki
目的：调查肺癌患者放射性肺炎 (RP) 的影像学特征，并确定高级别 RP 和 RP 相关死亡的影像学标志物。 方法：从放射肿瘤数据库中筛选出 82 例接受常规胸部放疗且出现症状 RP 的肺癌患者。研究了 RP 的影像学特征与高级别 RP（≥ 3 级）和 RP 相关死亡（5 级）的关系。结果： 60 例患者（73%）中 RP 为 2 级，15 例（18%）为 3 级，7 例（9%）为 5 级。较低的体能状态 (p=0.04)、鳞状细胞组织学 (p=0.03) 和 FEV1
Objective: Investigate the spectrum of radiographic patterns of radiation pneumonitis (RP) in lung cancer patients and identify imaging markers for high-grade RP and RP-related death.Methods: Eighty-two patients with lung cancer treated with conventional chest radiotherapy who had symptomatic RP were identified from the radiation oncology database. The imaging features of RP were studied for association with high-grade RP (Grade >= 3) and RP-related death (Grade 5).Results: RP was Grade 2 in 60 (73%), Grade 3 in 15 (18%), and Grade 5 in 7 patients (9%). Lower performance status (p=0.04), squamous cell histology (p=0.03), and FEV1