Varied actions of proinflammatory cytokines on excitotoxic cell death in the rat central nervous system
Varied actions of proinflammatory cytokines on excitotoxic cell death in the rat central nervous system
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DOI：
10.1002/jnr.10142
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发表时间：
2002-02-15
影响因子：
4.2
通讯作者：
Allan, SM
中科院分区：
文献类型：
--
作者：
Allan, SM
白细胞介素（IL）-1 β可介导多种形式的神经退行性变，并加剧大鼠脑内纹状体注射兴奋性毒素α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）诱导的细胞死亡。本研究的目的是确定这种效应是否特异于IL-1 β。在纹状体注射IL-1 α和AMPA的效果与IL-1 β相同，而同时注射IL-6或肿瘤坏死因子（TNF）-α和AMPA则不能诱导显著的皮质细胞死亡。与IL-1 α、IL-1 β和IL-6相比，TNF α显著减少了（38%）局部纹状体损伤。这些发现表明，IL-1对AMPA受体介导的细胞死亡在大鼠纹状体的效果是不模仿其他促炎细胞因子。此外，TNF α显示出对急性兴奋性毒性损伤的神经保护作用。(C)2002 Wiley-Liss，Inc.
Interleukin (IL)-1beta mediates diverse forms of neurodegeneration and exacerbates cell death induced by striatal injection of the excitotoxin alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) in the rat brain. The objective of this study was to determine whether this effect was specific to IL-1beta. Injection of IL-1alpha and AMPA in the striatum had effects identical to those of IL-1beta, whereas coinjection of IL-6 or tumor necrosis factor (TNF)-alpha with AMPA failed to induce significant cortical cell death. In contrast to IL-1alpha, IL-1beta, and IL-6, TNFalpha significantly reduced (by 38%) the local striatal damage. These findings suggest that the effect of IL-1 on AMPA receptor-mediated cell death in the rat striatum is not mimicked by other proinflammatory cytokines. Furthermore, TNFalpha shows neuroprotective effects against acute excitotoxic injury. (C) 2002 Wiley-Liss, Inc.