Properdin: a tightly regulated critical inflammatory modulator.
Properdin: a tightly regulated critical inflammatory modulator.
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DOI：
10.1111/imr.12466
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发表时间：
2016-11
影响因子：
8.7
通讯作者：
Ferreira VP
中科院分区：
文献类型：
--
作者：
Blatt AZ;Pathan S;Ferreira VP
补体替代途径是先天免疫系统的强大武器，可增强人类宿主的多种炎症反应。备解素是旁路途径作用的关键，它是一种血清糖蛋白，可以启动和正向调节旁路途径活性。备解素由许多不同的白细胞亚群产生，并作为单体亚基的环状寡聚体循环。虽然在纯化的备解素制剂中形成非生理性聚集体和血清中存在潜在的备解素抑制剂使其功能的研究变得复杂，但备解素无论如何都已成为各种炎性疾病模型中的关键参与者。在这里，我们回顾了基本的备解素生物学，强调了使以备解素为中心的研究结果解释复杂化的主要障碍。此外，我们阐述了备解素在血栓炎症中的新作用，并讨论了备解素抑制剂作为长期治疗选择的潜在效用，以治疗以血小板/粒细胞聚集体形成增加为标志的疾病。最后，我们描述了备解素和替代途径负调节因子H之间的相互作用，以及如何旨在了解这些相互作用可以为科学家提供最有效的方法来操纵复杂系统中的替代途径激活。
The complement alternative pathway is a powerful arm of the innate immune system that enhances diverse inflammatory responses in the human host. Key to the effects of the alternative pathway is properdin, a serum glycoprotein that can both initiate and positively regulate alternative pathway activity. Properdin is produced by many different leukocyte subsets and circulates as cyclic oligomers of monomeric subunits. While the formation of non‐physiological aggregates in purified properdin preparations and the presence of potential properdin inhibitors in serum have complicated studies of its function, properdin has, regardless, emerged as a key player in various inflammatory disease models. Here, we review basic properdin biology, emphasizing the major hurdles that have complicated the interpretation of results from properdin‐centered studies. In addition, we elaborate on an emerging role for properdin in thromboinflammation and discuss the potential utility of properdin inhibitors as long‐term therapeutic options to treat diseases marked by increased formation of platelet/granulocyte aggregates. Finally, we describe the interplay between properdin and the alternative pathway negative regulator, Factor H, and how aiming to understand these interactions can provide scientists with the most effective ways to manipulate alternative pathway activation in complex systems.
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DOI：
10.4049/jimmunol.0903678
发表时间：
2010-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Amara U;Flierl MA;Rittirsch D;Klos A;Chen H;Acker B;Brückner UB;Nilsson B;Gebhard F;Lambris JD;Huber-Lang M
通讯作者：
Huber-Lang M
影响因子：
20.3
作者：
Camous, Laurent;Roumenina, Lubka;Halbwachs-Mecarelli, Lise
通讯作者：
Halbwachs-Mecarelli, Lise
DOI：
10.1089/mab.2014.0066
发表时间：
2015-02-01
影响因子：
--
作者：
Bertram, Paula;Akk, Antonina M.;Hourcade, Dennis E.
通讯作者：
Hourcade, Dennis E.
影响因子：
3.1
作者：
Cortes, Claudio;Ferreira, V. P.;Pangburn, Michael K.
通讯作者：
Pangburn, Michael K.
影响因子：
4.4
作者：
Agarwal, Sarika;Ferreira, Viviana P.;Ram, Sanjay
通讯作者：
Ram, Sanjay