Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair.
Dictyostelium discoideum as a Model to Assess Genome Stability Through DNA Repair.
复制标题
通过DNA修复评估盘状盘齿龙基因组稳定性的模型。
DOI：
10.3389/fcell.2021.752175
复制
发表时间：
2021
影响因子：
5.5
通讯作者：
Lakin ND
中科院分区：
文献类型：
--
作者：
Pears CJ;Brustel J;Lakin ND
通过修复DNA损伤来保持基因组完整性对人类健康至关重要，这些途径中的缺陷导致各种病理，最显著的是癌症。社会性阿米巴Dictyosteelium discoideum对DNA损伤剂具有显著的抗性，基因组分析显示它含有几种DNA修复途径组分的直系同源物，否则仅限于脊椎动物。这些包括范可尼贫血DNA链间交联和DNA链断裂修复途径。这些功能的丧失不仅导致恶性肿瘤，而且还导致神经变性、免疫缺陷和先天性异常。此外，D. discoideum显示出DNA修复因子的显着保守性，这些DNA修复因子是癌症和其他疗法的靶标，包括靶向治疗乳腺癌和卵巢癌的聚（ADP-核糖）聚合酶。这与D. discoideum，使其成为一个有吸引力的模型，以评估DNA修复的机制基础，提供新的见解，这些途径可以靶向治疗各种病理。在这里，我们描述的进展，了解DNA修复的机制，在D。discoideum，以及这些如何影响基因组的稳定性与理解恶性肿瘤的发展。
Preserving genome integrity through repair of DNA damage is critical for human health and defects in these pathways lead to a variety of pathologies, most notably cancer. The social amoeba Dictyostelium discoideum is remarkably resistant to DNA damaging agents and genome analysis reveals it contains orthologs of several DNA repair pathway components otherwise limited to vertebrates. These include the Fanconi Anemia DNA inter-strand crosslink and DNA strand break repair pathways. Loss of function of these not only results in malignancy, but also neurodegeneration, immune-deficiencies and congenital abnormalities. Additionally, D. discoideum displays remarkable conservations of DNA repair factors that are targets in cancer and other therapies, including poly(ADP-ribose) polymerases that are targeted to treat breast and ovarian cancers. This, taken together with the genetic tractability of D. discoideum, make it an attractive model to assess the mechanistic basis of DNA repair to provide novel insights into how these pathways can be targeted to treat a variety of pathologies. Here we describe progress in understanding the mechanisms of DNA repair in D. discoideum, and how these impact on genome stability with implications for understanding development of malignancy.
登录
查看更多内容
影响因子：
9.8
作者：
Bogliolo, Massimo;Schuster, Beatrice;Surralles, Jordi
通讯作者：
Surralles, Jordi
影响因子：
4
作者：
Couto, C. Anne-Marie;Hsu, Duen-Wei;Lakin, Nicholas D.
通讯作者：
Lakin, Nicholas D.
DOI：
10.1007/978-1-62703-302-2_16
发表时间：
2013-01-01
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Couto, Anne-Marie C;Lakin, Nicholas D;Pears, Catherine J
通讯作者：
Pears, Catherine J
影响因子：
64.8
作者：
Ahel, Ivan;Ahel, Dragana;West, Stephen C.
通讯作者：
West, Stephen C.
DOI：
10.1073/pnas.1814425116
发表时间：
2019-02-05
影响因子：
11.1
作者：
Bloomfield, Gareth;Paschke, Peggy;Urushihara, Hideko
通讯作者：
Urushihara, Hideko